{"id":"W4408176705","doi":"10.2196/65334","title":"Comparative Bioavailability of Low-dose Micronized-isotretinoin 16 mg & Conventional Isotretinoin 20 mg Under Fasting Condition in Healthy Adult Male Subjects: A Randomized, Single-dose, Two-way, Cross-over Study (Preprint)","year":2024,"lang":"en","type":"article","venue":"JMIR Dermatology","topic":"Acne and Rosacea Treatments and Effects","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Bioavailability; Isotretinoin; Medicine; Pharmacology; Randomized controlled trial; Internal medicine; Dermatology; Acne","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006225177,0.000450133,0.001736977,0.0003643237,0.0001483349,0.0000592947,0.0001278262,0.0002620062,0.00123103],"category_scores_gemma":[0.0001724013,0.0003578409,0.0003742055,0.0004523945,0.0007480208,0.0001873323,0.0001349881,0.0005144734,0.0002673687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003467762,"about_ca_system_score_gemma":0.0002836346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004379957,"about_ca_topic_score_gemma":0.0009834509,"domain_scores_codex":[0.9959078,0.001002879,0.001310563,0.0008623846,0.0003327583,0.000583616],"domain_scores_gemma":[0.9975458,0.001223737,0.0003541956,0.0004366585,0.0002628927,0.0001767662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1565049,0.01273438,0.7887082,0.004369043,0.001702852,0.001420441,0.009904606,0.0001508772,0.01456602,0.001465931,0.007848995,0.0006237307],"study_design_scores_gemma":[0.7413981,0.002907878,0.2196847,0.003224771,0.000893546,0.005474512,0.005850847,0.007357425,0.008815239,0.001661149,0.001354344,0.001377447],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904471,0.001629411,0.0003447165,0.001325802,0.0003864092,0.004308099,0.00009617244,0.0001195364,0.001342754],"genre_scores_gemma":[0.9976363,0.00004051507,0.0002349645,0.00040504,0.00007938836,0.0005320246,0.0004032874,0.00003779496,0.0006307387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5848932,"threshold_uncertainty_score":0.9998873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02603294144631574,"score_gpt":0.3596037989600027,"score_spread":0.333570857513687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}