{"id":"W4408179056","doi":"10.1200/jco.24.00727","title":"Randomized, Open-Label, Phase III Study of Tilsotolimod in Combination With Ipilimumab Versus Ipilimumab Alone in Patients With Advanced Refractory Melanoma (ILLUMINATE-301)","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); University of Alberta; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Ipilimumab; Medicine; Refractory (planetary science); Internal medicine; Melanoma; Oncology; Open label; Randomized controlled trial; Cancer; Cancer research; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00261426,0.001731553,0.003896401,0.0004750897,0.00054829,0.001215556,0.001083202,0.001678974,0.007364076],"category_scores_gemma":[0.002020427,0.0009880615,0.001796501,0.0005411291,0.001451489,0.001209022,0.0004820473,0.003217402,0.001540568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001077319,"about_ca_system_score_gemma":0.001710178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032047,"about_ca_topic_score_gemma":0.002817867,"domain_scores_codex":[0.999064,0.0005193173,0.00004719001,0.0001798162,0.00006928897,0.0001204145],"domain_scores_gemma":[0.9986717,0.0003444401,0.0002967124,0.0001011336,0.0001030296,0.0004831418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9778446,0.008547533,0.0004793925,0.0004045676,0.0005980782,0.00002786705,0.00003460762,0.0002463917,0.002509773,0.00007383958,0.0009198596,0.008313338],"study_design_scores_gemma":[0.9327773,0.06508612,0.0008313426,0.00001810884,0.0002055727,0.00002037235,0.00001186081,0.0002343626,0.0002020881,0.0001016909,0.0005019269,0.000009258893],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.963508,0.005714581,0.00163449,0.001004806,0.001350923,0.01959872,0.00288413,0.0002428274,0.004061418],"genre_scores_gemma":[0.9672396,0.003287689,0.002874051,0.002124216,0.000847173,0.01611306,0.001968424,0.00004855003,0.005497361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007364076,"threshold_uncertainty_score":0.02463526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06245796240546921,"score_gpt":0.4472208119043379,"score_spread":0.3847628494988687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}