{"id":"W4408182402","doi":"10.1136/bmjopen-2024-095357","title":"Circadian rhythmicity of symptomatic phenotypes in multiple sclerosis: the CircaMS study protocol and feasibility of biomarker collection","year":2025,"lang":"en","type":"article","venue":"BMJ Open","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"Faculty of Health Sciences, Queen's University","keywords":"Medicine; Circadian rhythm; Biomarker; Multiple sclerosis; Protocol (science); Phenotype; Bioinformatics; Internal medicine; Pathology; Psychiatry; Alternative medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0217443,0.001707261,0.001419208,0.0008809974,0.002930489,0.001685256,0.002085204,0.002446781,0.006622056],"category_scores_gemma":[0.01685757,0.001277933,0.001315947,0.001274525,0.001358126,0.001341092,0.001921132,0.00161724,0.003530655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001549661,"about_ca_system_score_gemma":0.008996097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004956125,"about_ca_topic_score_gemma":0.006439484,"domain_scores_codex":[0.9910981,0.005760795,0.0009307853,0.000856209,0.0006845133,0.0006695997],"domain_scores_gemma":[0.9910806,0.00117901,0.001641309,0.002082368,0.002556534,0.001460235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.3521499,0.05296183,0.4024005,0.005300179,0.001393938,0.001483634,0.006884456,0.003963519,0.00994994,0.006747694,0.055446,0.1013185],"study_design_scores_gemma":[0.1016774,0.09513842,0.7009041,0.001449882,0.000746596,0.0008964253,0.002015161,0.00420454,0.00282815,0.003454988,0.08633901,0.0003452742],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.2371514,0.000885781,0.0127317,0.001006911,0.0004340759,0.7279607,0.0127369,0.000240008,0.006852489],"genre_scores_gemma":[0.1072916,0.0002091015,0.009857506,0.0004159183,0.0001667691,0.8776028,0.003424616,0.00002559419,0.001006005],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0217443,"threshold_uncertainty_score":0.1149962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2358546915515417,"score_gpt":0.454717681154119,"score_spread":0.2188629896025774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}