{"id":"W4408184346","doi":"10.26685/urncst.680","title":"Zinc Finger Nucleases (ZFNs) and Gene Therapy Applications","year":2025,"lang":"en","type":"article","venue":"Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Zinc finger nuclease; Genome editing; Biology; Gene; DNA; Computational biology; Non-homologous end joining; Genetics; Nuclease; DNA repair; Gene targeting; Zinc finger; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008121329,0.0006458806,0.0005456803,0.0009942586,0.0003821192,0.001305442,0.0007238173,0.001419092,0.004702457],"category_scores_gemma":[0.0007772219,0.0002521778,0.0004308,0.001372928,0.0009174209,0.001306994,0.001133575,0.001384242,0.003456366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001132427,"about_ca_system_score_gemma":0.0008285539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008553063,"about_ca_topic_score_gemma":0.0005663761,"domain_scores_codex":[0.9989023,0.00009994795,0.00008079579,0.0003092063,0.000491901,0.0001157442],"domain_scores_gemma":[0.9996967,0.00007099986,0.00006956029,0.00002103852,0.0001015498,0.00004015216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003048357,0.0001197655,0.001220723,0.003279641,0.00004801663,0.0004933417,0.0001863889,0.001471979,0.1498422,0.07930744,0.03847329,0.7252523],"study_design_scores_gemma":[0.00001816637,0.0001691882,0.0007300478,0.0002556599,0.00002412026,0.001433017,0.00004108221,0.0007258449,0.06954401,0.008705912,0.9183215,0.00003142702],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02325878,0.6813502,0.1714375,0.007399258,0.004214612,0.0004172632,0.00195701,0.001892724,0.1080727],"genre_scores_gemma":[0.2218674,0.5275957,0.1122487,0.005379164,0.002219342,0.0006040667,0.003852988,0.0002007772,0.1260319],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004702457,"threshold_uncertainty_score":0.01573128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02801996828005731,"score_gpt":0.4362655855191194,"score_spread":0.4082456172390621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}