{"id":"W4408187558","doi":"10.1159/000544818","title":"ECLIPSE-PV: A Randomized, Multicenter Study to Assess Efficacy, Safety, and Tolerability of Two Dosing Regimens of Ropeginterferon Alfa-2b-Njft in Polycythemia Vera","year":2025,"lang":"en","type":"article","venue":"Acta Haematologica","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Ottawa; Jewish General Hospital; St. Michael's Hospital; University of British Columbia; McGill University; University of Calgary; McMaster University; St. Paul's Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Tolerability; Dosing; Polycythemia vera; Medicine; Multicenter study; Randomized controlled trial; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003004253,0.001550696,0.001925617,0.0003669423,0.0003773133,0.0009180807,0.0008797445,0.001415831,0.004253044],"category_scores_gemma":[0.001958055,0.0007459262,0.001291154,0.0003878568,0.001050014,0.0008136433,0.0004486518,0.00246426,0.0006501355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001195525,"about_ca_system_score_gemma":0.001762974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001317253,"about_ca_topic_score_gemma":0.002635759,"domain_scores_codex":[0.998828,0.0006846971,0.00005633112,0.0001666726,0.000086145,0.0001782265],"domain_scores_gemma":[0.9984868,0.0003594265,0.0004151911,0.000147233,0.0000926132,0.0004988054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9575852,0.01969349,0.002245721,0.0002407033,0.0004117671,0.00004509369,0.00004362739,0.0003027757,0.003554477,0.00009514332,0.000884298,0.01489769],"study_design_scores_gemma":[0.8130451,0.1818156,0.003482509,0.00001487958,0.0002012361,0.00004797359,0.0000176537,0.0003452621,0.0004200335,0.00004927723,0.0005498106,0.00001065507],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926569,0.001333585,0.0004832987,0.0002767314,0.0001701495,0.003042007,0.0007408485,0.00007359203,0.001222859],"genre_scores_gemma":[0.9904088,0.0006941029,0.001426642,0.0006682784,0.0003079803,0.003260236,0.001351395,0.00002137754,0.001861015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004253044,"threshold_uncertainty_score":0.01588821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03175080926879111,"score_gpt":0.3492806947068883,"score_spread":0.3175298854380972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}