{"id":"W4408187558","doi":"10.1159/000544818","title":"ECLIPSE-PV: A Randomized, Multicenter Study to Assess Efficacy, Safety, and Tolerability of Two Dosing Regimens of Ropeginterferon Alfa-2b-Njft in Polycythemia Vera","year":2025,"lang":"en","type":"article","venue":"Acta Haematologica","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Ottawa; Jewish General Hospital; St. Michael's Hospital; University of British Columbia; McGill University; University of Calgary; McMaster University; St. Paul's Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Tolerability; Dosing; Polycythemia vera; Medicine; Multicenter study; Randomized controlled trial; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007610064,0.0002906325,0.002026047,0.0002198436,0.0000571039,0.00001804535,0.0001373722,0.00008334179,0.00008615055],"category_scores_gemma":[0.0008715929,0.0001944593,0.0001623535,0.0002728263,0.0001807013,0.00006020049,0.0002241219,0.0001989697,0.000003375161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000116807,"about_ca_system_score_gemma":0.00007615858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003103811,"about_ca_topic_score_gemma":0.0002271067,"domain_scores_codex":[0.9975153,0.0004482744,0.0009941281,0.0005252312,0.0002340116,0.000283041],"domain_scores_gemma":[0.9973996,0.001589709,0.0002476148,0.0005199504,0.0001352776,0.0001078479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1388405,0.01013102,0.8379647,0.0004578184,0.000944104,0.0001912632,0.005456867,0.00003884181,0.001989385,0.001427436,0.0003307763,0.002227377],"study_design_scores_gemma":[0.4369422,0.003603697,0.4843747,0.00325672,0.001346533,0.00008225894,0.002744471,0.000786764,0.06552172,0.000384108,0.0004358344,0.0005210779],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913911,0.0001879126,0.00009570175,0.002877421,0.0001095739,0.003441478,0.00001183623,0.00002498485,0.001859948],"genre_scores_gemma":[0.9983007,0.00009517508,0.001090359,0.0002464027,0.00001820854,0.0001352065,0.000008257747,0.00001287085,0.00009280517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.35359,"threshold_uncertainty_score":0.7929821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03175080926879111,"score_gpt":0.3492806947068883,"score_spread":0.3175298854380972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}