{"id":"W4408196175","doi":"10.1007/s00415-025-12966-9","title":"Tau levels in platelets isolated from Huntington’s disease patients serve as a biomarker of disease severity","year":2025,"lang":"en","type":"article","venue":"Journal of Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Hôtel-Dieu de Montréal; Université Laval; Polytechnique Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute; Montreal Neurological Institute and Hospital; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; University of Guelph","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Alzheimerfonden; Hjärnfonden; NIHR Cambridge Biomedical Research Centre; European Commission; University College London; HORIZON EUROPE Framework Programme; Wellcome Trust; European Partnership on Metrology; UK Research and Innovation; National Institute for Health and Care Research; HORIZON EUROPE Marie Sklodowska-Curie Actions; EU Joint Programme – Neurodegenerative Disease Research; Familjen Erling-Perssons Stiftelse; Stiftelsen för Gamla Tjänarinnor; Huntington's Disease Society of America; Alzheimer's Association; UK Dementia Research Institute; Vetenskapsrådet; Cure Alzheimer's Fund; Alzheimer's Drug Discovery Foundation","keywords":"Huntington's disease; Disease; Biomarker; Neurology; Neuroradiology; Medicine; Platelet; Internal medicine; Degenerative disease; Oncology; Pathology; Psychiatry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133258,0.0002349153,0.000442801,0.0004333342,0.00006174545,0.00002693774,0.0005152026,0.00007710585,0.0001361891],"category_scores_gemma":[0.002851848,0.0002184537,0.0002000151,0.0005139718,0.000177997,0.0001912172,0.0002123771,0.0003519799,0.00001123082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000259967,"about_ca_system_score_gemma":0.0003739041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003461151,"about_ca_topic_score_gemma":0.00001212997,"domain_scores_codex":[0.9970969,0.0008721173,0.0008540645,0.0004604218,0.0003831391,0.0003333325],"domain_scores_gemma":[0.9979619,0.0005443957,0.0006004439,0.0003448871,0.0002198376,0.0003284962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006638539,0.00170385,0.7631135,0.0000660756,0.00003692,0.0008515065,0.0001113475,0.0006117181,0.2248789,0.00006536204,0.0008247253,0.001097575],"study_design_scores_gemma":[0.001969912,0.0003321863,0.9423553,0.00004741146,0.00006788649,0.000003363497,0.000003345856,0.0008587803,0.05185264,0.002095237,0.0002792107,0.0001347084],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966165,0.000077128,0.0000422653,0.001892456,0.0008019034,0.0002478136,0.0002247889,0.00001244471,0.00008464816],"genre_scores_gemma":[0.9951487,0.00003214946,0.00001980997,0.004693717,0.00003312743,0.000005289784,0.000004276525,0.00002035418,0.00004261625],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1792418,"threshold_uncertainty_score":0.8908283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02319444228980618,"score_gpt":0.2810007810182349,"score_spread":0.2578063387284288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}