{"id":"W4408196175","doi":"10.1007/s00415-025-12966-9","title":"Tau levels in platelets isolated from Huntington’s disease patients serve as a biomarker of disease severity","year":2025,"lang":"en","type":"article","venue":"Journal of Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Hôtel-Dieu de Montréal; Université Laval; Polytechnique Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute; Montreal Neurological Institute and Hospital; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; University of Guelph","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Alzheimerfonden; Hjärnfonden; NIHR Cambridge Biomedical Research Centre; European Commission; University College London; HORIZON EUROPE Framework Programme; Wellcome Trust; European Partnership on Metrology; UK Research and Innovation; National Institute for Health and Care Research; HORIZON EUROPE Marie Sklodowska-Curie Actions; EU Joint Programme – Neurodegenerative Disease Research; Familjen Erling-Perssons Stiftelse; Stiftelsen för Gamla Tjänarinnor; Huntington's Disease Society of America; Alzheimer's Association; UK Dementia Research Institute; Vetenskapsrådet; Cure Alzheimer's Fund; Alzheimer's Drug Discovery Foundation","keywords":"Huntington's disease; Disease; Biomarker; Neurology; Neuroradiology; Medicine; Platelet; Internal medicine; Degenerative disease; Oncology; Pathology; Psychiatry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000165019,0.000328651,0.0002911435,0.0008041143,0.0002230788,0.0004567518,0.00010875,0.0002960353,0.0009274097],"category_scores_gemma":[0.0003957778,0.000107766,0.0001286078,0.0005054744,0.0001417133,0.0001319516,0.0001657869,0.000468673,0.0002365295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007168525,"about_ca_system_score_gemma":0.0000739126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003715919,"about_ca_topic_score_gemma":0.000573636,"domain_scores_codex":[0.9998,0.00003754416,0.00003638003,0.00004595451,0.00005712301,0.00002309515],"domain_scores_gemma":[0.9998285,0.00003848052,0.00005005651,0.00001443575,0.00003967488,0.00002885446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00157666,0.0002496485,0.1798797,0.0002148632,0.0002325023,0.001805105,0.0007664799,0.0001142711,0.7969915,0.0001125899,0.000476125,0.01758059],"study_design_scores_gemma":[0.00006428048,0.001928298,0.8228236,0.00005384837,0.0002568797,0.006344501,0.0005224494,0.0007469859,0.1646195,0.0002501877,0.002365965,0.00002339703],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944424,0.002671163,0.001107799,0.00006723581,0.00004310111,0.00003291033,0.0005596929,0.00002335208,0.00105239],"genre_scores_gemma":[0.9962465,0.0007743602,0.001282102,0.0000675352,0.00004314324,0.00004103133,0.0008091411,0.000006882404,0.0007293092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009274097,"threshold_uncertainty_score":0.003102541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02319444228980618,"score_gpt":0.2810007810182349,"score_spread":0.2578063387284288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}