{"id":"W4408197516","doi":"10.1038/s41467-025-57556-5","title":"Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; U.S. Department of Health and Human Services; National Institutes of Health; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging","keywords":"Chromatin; Nucleosome; PHD finger; Cell biology; H3K4me3; Histone; Biology; Histone methyltransferase; Genetics; Computational biology; DNA; Gene; Transcription factor; Promoter; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001300787,0.0001889457,0.0001552345,0.0001712618,0.000139785,0.0002060707,0.0002561551,0.0002404596,0.001794927],"category_scores_gemma":[0.0001131362,0.0001212147,0.0002001004,0.0001079746,0.0001342175,0.0001425944,0.0002059862,0.0002010402,0.0005171982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003785812,"about_ca_system_score_gemma":0.0001042668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006631188,"about_ca_topic_score_gemma":0.0006084945,"domain_scores_codex":[0.9999373,0.00001027334,0.000003686843,0.00001542229,0.00002007148,0.00001333558],"domain_scores_gemma":[0.9999382,0.00001099141,0.00002161178,0.000003152156,0.00000799513,0.00001807608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002512168,0.00002541258,0.004331073,0.00005203678,0.00001633797,0.00009143851,0.0000157376,0.000620072,0.9916504,0.0002491944,0.0000838891,0.00261324],"study_design_scores_gemma":[0.00003928607,0.0002793958,0.08061276,0.00000873393,0.00004995132,0.0006438683,0.00006496491,0.0243193,0.8893874,0.0003719787,0.00420735,0.00001504005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936541,0.00345684,0.001677484,0.00009793651,0.000008531261,0.000007039402,0.0001750898,0.00005078598,0.0008721639],"genre_scores_gemma":[0.9977489,0.0003507952,0.0005887327,0.00001823745,0.000003959483,0.000003854815,0.0002543216,0.000003001989,0.001028239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001794927,"threshold_uncertainty_score":0.006004632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007749604092149928,"score_gpt":0.2830795575365305,"score_spread":0.2753299534443806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}