{"id":"W4408198748","doi":"10.3390/cells14050385","title":"Selective Azapeptide CD36 Ligand MPE-298 Regulates oxLDL-LOX-1-Mediated Inflammation and Mitochondrial Oxidative Stress in Macrophages","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; McGill University; University of Alberta; Université de Montréal","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"CD36; Chemistry; Oxidative stress; NADPH oxidase; Reactive oxygen species; Cell biology; Inflammation; Mitochondrion; Receptor; Biochemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001195939,0.0001671625,0.0003167082,0.0001164121,0.0001279346,0.0001684443,0.0001177247,0.0002620973,0.0008050638],"category_scores_gemma":[0.00007817951,0.00008444305,0.0001407756,0.00008250849,0.0002136067,0.0001714118,0.0001358742,0.0004438988,0.0002658822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000161189,"about_ca_system_score_gemma":0.0001234593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001791248,"about_ca_topic_score_gemma":0.0002249903,"domain_scores_codex":[0.9999055,0.00002005464,0.00000921651,0.00001649297,0.00002015607,0.00002864451],"domain_scores_gemma":[0.9999534,0.000005927631,0.00001407727,0.000003621789,0.000008002315,0.00001495431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004423905,0.00004719001,0.0001106156,0.00003974752,0.000002820585,0.00006490074,0.00001737723,0.00003116803,0.9981574,0.00005077733,0.00002991669,0.001005648],"study_design_scores_gemma":[0.000112508,0.001121322,0.007038002,0.00001003781,0.00002714936,0.0006499355,0.00008302882,0.001652878,0.9863003,0.0001374506,0.002859076,0.000008326318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939172,0.003646685,0.001565491,0.0001228686,0.00002549554,0.00002613935,0.00007741778,0.00003306808,0.0005856814],"genre_scores_gemma":[0.9956672,0.001604421,0.001056138,0.00007779654,0.00001604657,0.00004707515,0.0001149424,0.000005863558,0.001410517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008050638,"threshold_uncertainty_score":0.002693176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004008623451631306,"score_gpt":0.2029635282373983,"score_spread":0.198954904785767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}