{"id":"W4408215760","doi":"10.3390/parasitologia5010012","title":"Characterization of a Choline-Gated Chloride Channel (LGC-40) from Haemonchus contortus Highlights a Novel Cholinergic Binding Site","year":2025,"lang":"en","type":"article","venue":"Parasitologia","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Haemonchus contortus; Cholinergic; Chloride channel; Acetylcholine; Acetylcholine receptor; Choline; Xenopus; Ligand-gated ion channel; Biology; Neurotransmitter receptor; Choline chloride; Ligand (biochemistry); Ion channel; Biochemistry; Chemistry; Receptor; Nematode; Pharmacology; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007017111,0.0001674866,0.0001722406,0.000164916,0.0001272073,0.0001568535,0.0001719133,0.0003597788,0.0006308252],"category_scores_gemma":[0.0002091282,0.00004772459,0.0002088164,0.0001173977,0.0001774847,0.000188821,0.0001515398,0.0002653907,0.0002535782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002298207,"about_ca_system_score_gemma":0.0003482857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00172614,"about_ca_topic_score_gemma":0.001886044,"domain_scores_codex":[0.9999573,0.000003350815,0.000003667901,0.000009096299,0.00001753707,0.000008996344],"domain_scores_gemma":[0.9998902,0.00002146347,0.00002332884,0.000007609965,0.00001815255,0.00003927421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002356757,0.000007267957,0.0003701682,0.00002580492,0.000002705548,0.0001611604,0.00002223021,0.00003329778,0.998656,0.00003806202,0.00001947636,0.0006401337],"study_design_scores_gemma":[0.00003336665,0.00054413,0.07536876,0.00003205493,0.0000483866,0.005590709,0.0002492158,0.003683041,0.9046053,0.0003446615,0.009466629,0.00003380736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970766,0.0004952273,0.001255297,0.0001356804,0.000009690903,0.00002513097,0.0003669068,0.00003052834,0.0006049129],"genre_scores_gemma":[0.993588,0.0004098034,0.002916493,0.0001073463,0.000008267151,0.00001718685,0.001700476,0.00001198712,0.001240441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00172614,"threshold_uncertainty_score":0.003432214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02549235628234634,"score_gpt":0.3036410055326655,"score_spread":0.2781486492503192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}