{"id":"W4408216701","doi":"10.7554/elife.105404.1.sa4","title":"Author response: Notch signaling maintains a progenitor-like subclass of hepatocellular carcinoma","year":2025,"lang":"en","type":"peer-review","venue":"","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Microsemi (Canada)","funders":"","keywords":"Subclass; Hepatocellular carcinoma; Progenitor cell; Progenitor; Notch signaling pathway; Biology; Cancer research; Cell biology; Immunology; Signal transduction; Stem cell; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001354148,0.0004797438,0.0004476545,0.001189909,0.0007891795,0.001891083,0.0006832194,0.0008693334,0.08397592],"category_scores_gemma":[0.007028702,0.00015694,0.0001543413,0.0006931112,0.0006534474,0.001117096,0.001114834,0.0007489899,0.06314435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007255708,"about_ca_system_score_gemma":0.001607279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008820733,"about_ca_topic_score_gemma":0.002749302,"domain_scores_codex":[0.9986059,0.0001627926,0.00007584178,0.0001989166,0.0008770521,0.00007952351],"domain_scores_gemma":[0.9930693,0.0006026317,0.0003356028,0.0003528573,0.004795677,0.0008439308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000309368,0.00004515667,0.00216331,0.001861851,0.00003032513,0.001297107,0.0004473176,0.0003705236,0.05963508,0.004204673,0.5895981,0.3400373],"study_design_scores_gemma":[0.00000877642,0.00002053751,0.001705629,0.00006606602,0.000006673775,0.0004190779,0.0001403746,0.000109253,0.006508859,0.0004607147,0.9905438,0.00001037825],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.07374979,0.06095756,0.0228913,0.1061197,0.1820101,0.001413877,0.0075188,0.005842171,0.5394967],"genre_scores_gemma":[0.07132216,0.01571674,0.004998946,0.002857843,0.01334268,0.00009267125,0.002349831,0.001033068,0.888286],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.08397592,"threshold_uncertainty_score":0.2809274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03118544622902431,"score_gpt":0.3172108721114529,"score_spread":0.2860254258824286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}