{"id":"W4408230279","doi":"10.1101/2025.03.01.640950","title":"Amyloid beta is released by lysosomal exocytosis from hiPSC-derived neurons","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Exocytosis; BETA (programming language); Amyloid (mycology); Chemistry; Amyloid beta; Neuroscience; Cell biology; Biophysics; Biology; Biochemistry; Computer science; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001777089,0.0002004992,0.0002926965,0.0001875296,0.0001303552,0.0003675768,0.0001589984,0.0001916843,0.0008664585],"category_scores_gemma":[0.0001048378,0.0000733767,0.0002510819,0.000178836,0.0001774984,0.0001307699,0.0002379822,0.0004059986,0.00052865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003128907,"about_ca_system_score_gemma":0.0001861482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001316676,"about_ca_topic_score_gemma":0.0009019704,"domain_scores_codex":[0.9998857,0.000009240759,0.00001556716,0.00002316868,0.00004454347,0.00002176286],"domain_scores_gemma":[0.9999431,0.00001259802,0.00001036886,0.00001199318,0.00001251406,0.000009417054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008296619,0.00001207269,0.0003006606,0.00003905416,0.00001022414,0.0001548931,0.00002500627,0.00007761613,0.9975438,0.000103404,0.00009247368,0.001557826],"study_design_scores_gemma":[0.00001501667,0.00004993756,0.003408578,0.000006868173,0.00001032941,0.0002575263,0.00002515846,0.001333789,0.9934095,0.00006201923,0.00141699,0.000004316948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858833,0.001672142,0.00721712,0.0001151309,0.00006563315,0.0000437131,0.001548758,0.0001703283,0.003283917],"genre_scores_gemma":[0.9879189,0.0007942948,0.005067344,0.00006582357,0.00001343506,0.00004976092,0.001867832,0.00005159958,0.004171055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001316676,"threshold_uncertainty_score":0.002898633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009399076921716296,"score_gpt":0.2008656342962715,"score_spread":0.1914665573745552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}