{"id":"W4408235772","doi":"10.1038/s41467-025-57104-1","title":"Reply to: Do actin isoforms have unique functionalities at the protein level?","year":2025,"lang":"en","type":"letter","venue":"Nature Communications","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Gene isoform; Actin; Cell biology; Computational biology; Focus (optics); Biology; Genetics; Gene; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003138044,0.001024601,0.00125543,0.0006399122,0.002137054,0.002032203,0.001823491,0.02642705,0.004386342],"category_scores_gemma":[0.01554147,0.0006013076,0.0009417147,0.0005191952,0.003532132,0.004295099,0.001536395,0.03380103,0.006552149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002306927,"about_ca_system_score_gemma":0.001649228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001408679,"about_ca_topic_score_gemma":0.001378207,"domain_scores_codex":[0.9986897,0.0003433184,0.0001917991,0.0002545257,0.0003803643,0.0001403147],"domain_scores_gemma":[0.9942809,0.00343794,0.0003321661,0.0002064946,0.001141038,0.0006013993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001433955,0.00003915615,0.0005553637,0.0001170367,0.00001725498,0.002867548,0.0001308289,0.00008644263,0.0004803837,0.00248876,0.9820978,0.01097613],"study_design_scores_gemma":[0.0001508155,0.0001504397,0.001505635,0.0002337701,0.00004498073,0.007485894,0.0005447174,0.0008589228,0.001068943,0.01890107,0.9689349,0.0001198462],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0004533565,0.002349556,0.0003095924,0.9569578,0.03899136,0.00001342495,0.00006447826,0.00006409152,0.0007962435],"genre_scores_gemma":[0.005397973,0.002679365,0.0005207119,0.9203919,0.06626818,0.00005301807,0.00004488215,0.00003659836,0.004607439],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02642705,"threshold_uncertainty_score":0.016738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02478555755345844,"score_gpt":0.2938343955662599,"score_spread":0.2690488380128014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}