{"id":"W4408243532","doi":"10.1002/chem.202500581","title":"Pseudo‐Ring Methodology to Control the Conformations of Macrocyclic Peptides","year":2025,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Molecular Sensors and Ion Detection","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Ring (chemistry); Covalent bond; Hydrogen bond; Chemistry; Molecule; Fluorescence; Stereochemistry; Organic chemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007097705,0.0001267581,0.0001815482,0.00003798776,0.0002409312,0.00006940415,0.0003523808,0.00003809087,0.0005936468],"category_scores_gemma":[0.0004912461,0.00009717987,0.0001488175,0.0001320032,0.00007003312,0.00004173994,0.00006870446,0.0004279694,0.00002402495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003681835,"about_ca_system_score_gemma":0.00004012218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002064244,"about_ca_topic_score_gemma":2.865369e-7,"domain_scores_codex":[0.9989236,0.0001514376,0.0004660629,0.000129866,0.0001322041,0.0001968],"domain_scores_gemma":[0.9991202,0.0001338961,0.0002256782,0.0002880779,0.0001343978,0.00009772478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004869659,0.00001508697,0.00005477113,0.00006922321,0.00008410327,0.00001897949,0.0002083219,0.0003791669,0.9893305,0.00003697582,0.001454959,0.008299162],"study_design_scores_gemma":[0.001071693,0.0000166197,0.0003528267,0.000158526,0.00008815154,0.0005948068,0.000964736,0.00209373,0.9509599,0.00009753904,0.04345004,0.0001514745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8784958,0.0001329425,0.03133068,0.0007392135,0.0001105074,0.00004214649,0.000008737178,0.00003222545,0.08910782],"genre_scores_gemma":[0.9943389,0.00002822622,0.001098641,0.0003447807,0.0001811594,0.000002632795,0.000002165346,0.00001527684,0.003988244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1158431,"threshold_uncertainty_score":0.6500016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02127605369868784,"score_gpt":0.2658842166885161,"score_spread":0.2446081629898283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}