{"id":"W4408243951","doi":"10.1093/rheumatology/keaf128","title":"Belimumab concentrations and immunogenicity in relation to drug effectiveness and safety in SLE within a Swedish real-world setting","year":2025,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Erik och Edith Fernströms Stiftelse för Medicinsk Forskning; Vetenskapsrådet; Reumatikerförbundet; Linköpings Universitet; Svenska Läkaresällskapet; Gilead Sciences; GlaxoSmithKline; AstraZeneca; Bristol-Myers Squibb; Eli Lilly and Company; Ulla och Gustaf af Ugglas Stiftelse; Stiftelsen Konung Gustaf V:s 80-årsfond; Karolinska Institutet; Amgen; Nyckelfonden","keywords":"Belimumab; Medicine; Adverse effect; Internal medicine; Serology; Immunogenicity; Drug; Immunology; Pharmacology; Antibody; B-cell activating factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001026426,0.0001104687,0.0002508136,0.0001422084,0.0001119881,0.00001880877,0.00006621225,0.0001273965,0.0000160753],"category_scores_gemma":[0.0001989717,0.000102395,0.00002446438,0.0004097741,0.0001019413,0.00006909019,0.00009835032,0.0002918587,0.000002544873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008132157,"about_ca_system_score_gemma":0.00004162121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008129716,"about_ca_topic_score_gemma":0.003335306,"domain_scores_codex":[0.9986886,0.0005008797,0.0003014886,0.0002847537,0.00002051946,0.0002036979],"domain_scores_gemma":[0.9992617,0.0005210547,0.00004527517,0.0001276411,0.00002516575,0.00001909895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001424852,0.0001811609,0.7485558,0.0001311439,0.0001485119,0.00001280215,0.001944125,0.00007273822,0.2184543,0.01693425,0.0002863447,0.01185393],"study_design_scores_gemma":[0.001869045,0.00004041342,0.9787181,0.0002437781,0.000031567,0.000003613597,0.0001622959,0.0001327994,0.01572429,0.001509272,0.001434427,0.000130377],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946768,0.001218391,0.0003103171,0.001540303,0.0002386719,0.0004455877,0.00002295541,0.00002224621,0.001524748],"genre_scores_gemma":[0.998032,0.0001011245,0.0009578656,0.000286449,0.000006925672,0.00002128911,0.0000155508,0.000005026731,0.0005737337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2301623,"threshold_uncertainty_score":0.4175545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00930358386182029,"score_gpt":0.2902217957412761,"score_spread":0.2809182118794558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}