{"id":"W4408243951","doi":"10.1093/rheumatology/keaf128","title":"Belimumab concentrations and immunogenicity in relation to drug effectiveness and safety in SLE within a Swedish real-world setting","year":2025,"lang":"en","type":"article","venue":"Lara D. Veeken","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Erik och Edith Fernströms Stiftelse för Medicinsk Forskning; Vetenskapsrådet; Reumatikerförbundet; Linköpings Universitet; Svenska Läkaresällskapet; Gilead Sciences; GlaxoSmithKline; AstraZeneca; Bristol-Myers Squibb; Eli Lilly and Company; Ulla och Gustaf af Ugglas Stiftelse; Stiftelsen Konung Gustaf V:s 80-årsfond; Karolinska Institutet; Amgen; Nyckelfonden","keywords":"Belimumab; Medicine; Adverse effect; Internal medicine; Serology; Immunogenicity; Drug; Immunology; Pharmacology; Antibody; B-cell activating factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002655527,0.0003258916,0.0003911363,0.001223772,0.0002710021,0.001185159,0.0002304406,0.0003761673,0.001008916],"category_scores_gemma":[0.008240493,0.0002572263,0.0004906677,0.001088303,0.0005978355,0.0004699062,0.0006063103,0.0003840603,0.0001987771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004592641,"about_ca_system_score_gemma":0.0004064504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001834663,"about_ca_topic_score_gemma":0.001004823,"domain_scores_codex":[0.9975458,0.001375225,0.0003345633,0.0003092132,0.0002615099,0.000173764],"domain_scores_gemma":[0.9923699,0.002956822,0.00358237,0.0003533589,0.0004316201,0.0003058463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009238697,0.00004029102,0.993643,0.00007932232,0.0001553696,0.0001958614,0.0003505544,0.0005209654,0.0005118077,0.00003276168,0.00004524872,0.003500973],"study_design_scores_gemma":[0.00004008526,0.0008974174,0.9950801,0.00004204831,0.0001449806,0.001208899,0.0004843639,0.001101198,0.000514592,0.0001034402,0.0003676261,0.00001524983],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989296,0.0007574853,0.0000922223,0.0000169989,0.000002752223,0.000002979304,0.00006126445,0.000003439885,0.0001332896],"genre_scores_gemma":[0.999689,0.0001239516,0.0000675428,0.000005325349,0.000004028811,0.000003415108,0.00007484995,0.000001370266,0.00003049629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002655527,"threshold_uncertainty_score":0.01404393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00930358386182029,"score_gpt":0.2902217957412761,"score_spread":0.2809182118794558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}