{"id":"W4408244065","doi":"10.1056/nejmoa2408792","title":"Remibrutinib in Chronic Spontaneous Urticaria","year":2025,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Urticaria and Related Conditions","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Placebo; Angioedema; Adverse effect; Internal medicine; Clinical endpoint; Randomized controlled trial; Clinical trial; Gastroenterology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001101564,0.0003994744,0.000744086,0.0001711387,0.0002183126,0.0002554951,0.0002371473,0.0002900096,0.002429312],"category_scores_gemma":[0.0006279582,0.00007716752,0.0004006678,0.0002020772,0.0001890754,0.0001484074,0.0001851454,0.0005987895,0.0003917629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003459782,"about_ca_system_score_gemma":0.0003251961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002167192,"about_ca_topic_score_gemma":0.0006735868,"domain_scores_codex":[0.9997308,0.0001242899,0.00002721049,0.00002802005,0.00004267738,0.00004709368],"domain_scores_gemma":[0.9996648,0.0001191475,0.00008790792,0.00002215894,0.00002892519,0.00007703283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.08406604,0.004323351,0.02573162,0.003640564,0.001144869,0.001883884,0.0002360833,0.002676482,0.04891082,0.00092666,0.008594037,0.8178656],"study_design_scores_gemma":[0.300872,0.2553018,0.2609629,0.001466564,0.002784432,0.02846168,0.0003258531,0.006604197,0.03101084,0.002406473,0.1097222,0.0000811484],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9158263,0.07516357,0.0008694545,0.001216313,0.0002361551,0.0002990932,0.0003028922,0.0001004801,0.005985801],"genre_scores_gemma":[0.9878378,0.009377335,0.0005324613,0.000448598,0.0002367662,0.0001805995,0.0004217634,0.000006050598,0.0009585418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002429312,"threshold_uncertainty_score":0.008126855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01034419869419696,"score_gpt":0.2841689796614665,"score_spread":0.2738247809672695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}