{"id":"W4408244174","doi":"10.1002/ajmg.b.33026","title":"Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive‐Compulsive Disorder","year":2025,"lang":"en","type":"article","venue":"American Journal of Medical Genetics Part B Neuropsychiatric Genetics","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Mental Health; Uppsala Multidisciplinary Center for Advanced Computational Science; National Institutes of Health; Vetenskapsrådet; Trond Mohn stiftelse","keywords":"Schizophrenia (object-oriented programming); Clinical psychology; Cognition; Medicine; Psychiatry; Association (psychology); Cognitive behavioral therapy; Obsessive compulsive; Psychological intervention; Psychology; Psychotherapist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007336818,0.0005050722,0.0009721523,0.0004896487,0.0002239594,0.00008197993,0.0006777503,0.0003194838,0.0002125231],"category_scores_gemma":[0.000327149,0.0004761243,0.0004013857,0.00104452,0.0005550417,0.0000620893,0.0001753431,0.001027593,0.00001279426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008762162,"about_ca_system_score_gemma":0.0003409182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001126402,"about_ca_topic_score_gemma":0.00005395977,"domain_scores_codex":[0.9951255,0.001019046,0.001216866,0.0006627591,0.001162388,0.0008134933],"domain_scores_gemma":[0.9954287,0.001250548,0.001807378,0.0003759796,0.0006026414,0.0005347522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003995764,0.0005344086,0.6960461,0.00001373711,0.0006555233,0.00001934983,0.0008778618,0.000003754552,0.000003251514,0.00001179674,0.0007717669,0.3006628],"study_design_scores_gemma":[0.005556965,0.003942014,0.9771964,0.00007512887,0.001367927,0.00003105425,0.001518288,0.00009670204,0.00001411764,0.0004336575,0.009323023,0.0004447334],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9667575,0.01997216,0.005721609,0.003252523,0.003026229,0.000929751,0.0002490968,0.00002782091,0.00006327059],"genre_scores_gemma":[0.9791501,0.01643429,0.001055252,0.001834602,0.001213251,0.0001100859,0.00002122903,0.00008304778,0.00009817112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3002181,"threshold_uncertainty_score":0.999769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01603360746990105,"score_gpt":0.332986318787124,"score_spread":0.3169527113172229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}