{"id":"W4408244186","doi":"10.1002/ctm2.70266","title":"Exon junction complexes regulate osteoclast‐induced bone resorption by influencing the NFATc1 m6A distribution through the “shield effect”","year":2025,"lang":"en","type":"article","venue":"Clinical and Translational Medicine","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China","keywords":"Exon; DNA methylation; Osteoclast; Methylation; Bone resorption; Biology; Molecular biology; Gene; Cell biology; Chemistry; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000193064,0.0003186818,0.0002056914,0.0001671205,0.000220745,0.0003859955,0.0001922185,0.0003498092,0.001804542],"category_scores_gemma":[0.0002004891,0.0001814513,0.0003096212,0.00007987956,0.0003111576,0.0002323844,0.0003284844,0.0005345089,0.0004109668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002567175,"about_ca_system_score_gemma":0.0001940181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003624421,"about_ca_topic_score_gemma":0.0005479763,"domain_scores_codex":[0.9997649,0.00003194407,0.00002013435,0.00005764636,0.00007467545,0.00005072111],"domain_scores_gemma":[0.9998372,0.0000191477,0.00007209994,0.00001368365,0.00002322095,0.00003458186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008398504,0.00001130195,0.0005026247,0.00004441327,0.000007138789,0.00002903157,0.00001379474,0.0000415407,0.9979486,0.0001355083,0.00004386346,0.001138216],"study_design_scores_gemma":[0.00002481729,0.0001466998,0.008994544,0.00001039238,0.00003819729,0.0002941714,0.00003959322,0.0007607511,0.9854487,0.00007814087,0.004158251,0.000005766427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806617,0.005838525,0.01047694,0.000128819,0.00006167743,0.00003497204,0.0004377044,0.0002237385,0.002135782],"genre_scores_gemma":[0.9929265,0.001018022,0.002936639,0.00005361055,0.00001173563,0.00002180619,0.0003192661,0.00003073614,0.002681648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001804542,"threshold_uncertainty_score":0.006036758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02613973631829681,"score_gpt":0.3385333152625009,"score_spread":0.3123935789442041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}