{"id":"W4408244311","doi":"10.1002/pbc.31649","title":"Pegcetacoplan for Breakthrough Hemolysis in an Adolescent With Classical Paroxysmal Nocturnal Hemoglobinuria on Eculizumab","year":2025,"lang":"en","type":"letter","venue":"Pediatric Blood & Cancer","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; BC Children's Hospital; University of British Columbia","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Eculizumab; Medicine; Hemolysis; Hemoglobinuria; Pediatrics; Intensive care medicine; Immunology; Complement system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001504701,0.0008024938,0.001195543,0.0004886184,0.0002014126,0.00006919595,0.0007738093,0.001079195,0.0009478746],"category_scores_gemma":[0.00003587031,0.0006720573,0.0003584126,0.0004456706,0.0001248235,0.00009653432,0.0001255047,0.001833441,0.00007787964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003572215,"about_ca_system_score_gemma":0.001026989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003736205,"about_ca_topic_score_gemma":0.000802606,"domain_scores_codex":[0.9961832,0.0003901634,0.0008130615,0.001297084,0.0002103959,0.001106159],"domain_scores_gemma":[0.9981119,0.0003537817,0.0004793389,0.0008203282,0.0001701539,0.00006448749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001251643,0.0006992648,0.04776096,0.001394121,0.0006235881,0.0001990809,0.00008160927,0.00004322969,0.00005848648,0.0000177633,0.9471459,0.0007243144],"study_design_scores_gemma":[0.01700978,0.001739557,0.01777192,0.001080542,0.00645499,0.0001447527,0.00006568046,0.00001204417,0.000530163,0.00007288658,0.9532474,0.001870317],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5027415,0.0428803,0.0002543035,0.4089836,0.01286943,0.01071991,0.01906559,0.0007840556,0.001701254],"genre_scores_gemma":[0.634893,0.0009637763,0.0002869668,0.3167504,0.02136418,0.005296031,0.01093159,0.0003408134,0.009173209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1321515,"threshold_uncertainty_score":0.9999654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01982833760952447,"score_gpt":0.2827749198067754,"score_spread":0.262946582197251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}