{"id":"W4408244311","doi":"10.1002/pbc.31649","title":"Pegcetacoplan for Breakthrough Hemolysis in an Adolescent With Classical Paroxysmal Nocturnal Hemoglobinuria on Eculizumab","year":2025,"lang":"en","type":"letter","venue":"Pediatric Blood & Cancer","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; BC Children's Hospital; University of British Columbia","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Eculizumab; Medicine; Hemolysis; Hemoglobinuria; Pediatrics; Intensive care medicine; Immunology; Complement system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003493152,0.0004670621,0.0006467954,0.0006793464,0.001625058,0.000761146,0.0006990853,0.004969674,0.001848713],"category_scores_gemma":[0.002852753,0.0003236175,0.0005993798,0.0003651659,0.0008902746,0.0009884288,0.0003635344,0.005202587,0.0005742252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001723332,"about_ca_system_score_gemma":0.0009619042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004318291,"about_ca_topic_score_gemma":0.006522468,"domain_scores_codex":[0.9996439,0.00009532419,0.00003219022,0.00005636069,0.00007385616,0.00009834513],"domain_scores_gemma":[0.9991731,0.0003791917,0.00006674423,0.00003170564,0.00007017252,0.0002790926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0001756166,0.0001184491,0.01294609,0.00006539854,0.00004167237,0.9276103,0.0002587621,0.0003431763,0.0009002889,0.002619724,0.04550117,0.009419438],"study_design_scores_gemma":[0.0002114897,0.0002608073,0.01369271,0.0002941039,0.00007655787,0.9485571,0.0005218752,0.003466348,0.0009953744,0.003999932,0.02788107,0.00004267366],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.4112522,0.01634771,0.002794093,0.4970751,0.01413741,0.0001579454,0.0003923494,0.0003120589,0.05753127],"genre_scores_gemma":[0.9161195,0.004180016,0.001419916,0.05909921,0.01116776,0.00003899798,0.0001215023,0.00005909306,0.007793953],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004969674,"threshold_uncertainty_score":0.01250374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01982833760952447,"score_gpt":0.2827749198067754,"score_spread":0.262946582197251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}