{"id":"W4408244648","doi":"10.1155/jimr/3214633","title":"Chemically Induced Senescence Prompts Functional Changes in Human Microglia‐Like Cells","year":2025,"lang":"en","type":"article","venue":"Journal of Immunology Research","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Research on Brain Language and Music; Montreal Neurological Institute and Hospital; Université de Montréal","funders":"Canada Research Chairs; Health Canada; Azrieli Foundation; Parkinson Canada; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"Microglia; Senescence; Neuroinflammation; Biology; Cell biology; Proinflammatory cytokine; Inflammation; Neuroscience; Phenotype; Immune system; Neurodegeneration; Cell; Immunology; Medicine; Pathology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001204173,0.0001148355,0.0002210739,0.001070742,0.0002367373,0.00006917174,0.0005041897,0.0001358984,0.0001551511],"category_scores_gemma":[0.0006614426,0.0001043959,0.00005577207,0.0008722564,0.0001845732,0.0001617601,0.0001795853,0.00121332,0.00003978315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001021999,"about_ca_system_score_gemma":0.000302292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003413326,"about_ca_topic_score_gemma":0.00001429132,"domain_scores_codex":[0.9975845,0.0007594824,0.0004857968,0.0002846406,0.0005099652,0.0003756063],"domain_scores_gemma":[0.9987643,0.0003811622,0.0001817779,0.0002295804,0.0003881372,0.00005509204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001616965,0.0001362958,0.00008580631,0.00001278885,0.000005578569,0.0001008221,0.00007346109,0.000007907346,0.9956225,0.002215661,0.0009378574,0.0006396071],"study_design_scores_gemma":[0.0008290698,0.0002787866,0.001293699,0.00005011354,0.000002247157,0.0001177503,0.00004904093,0.00004050335,0.9949256,0.0008247498,0.00151909,0.00006937254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940445,0.0000539404,0.00009461257,0.00423074,0.000797342,0.000215309,0.000001275135,0.00001627807,0.0005460368],"genre_scores_gemma":[0.9962357,0.0001513126,0.00008467148,0.0006967686,0.0000860909,0.00001288219,6.085593e-7,0.00001101957,0.002720985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003533971,"threshold_uncertainty_score":0.5271339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1047342358837213,"score_gpt":0.3674580271081901,"score_spread":0.2627237912244688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}