{"id":"W4408244740","doi":"10.1021/jacs.4c12543","title":"Structure and pH Dependence of Membranolytic Mechanisms by Truncated Oxidized Phospholipids","year":2025,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Alliance de recherche numérique du Canada; China Scholarship Council; Thailand Science Research and Innovation; Universiteit Utrecht; Technische Universiteit Eindhoven; Fédération Wallonie-Bruxelles; Canada Research Chairs","keywords":"Chemistry; Membrane; Lipid bilayer; Biophysics; Bilayer; Molecule; Cell membrane; Carboxylic acid; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507773,0.0002531484,0.0001111718,0.00011539,0.0000875621,0.0001918095,0.0001869128,0.0002691092,0.0007852846],"category_scores_gemma":[0.0002996912,0.0001376528,0.0002248891,0.00007661116,0.0002468581,0.0003540912,0.000230534,0.0004228534,0.0001783075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002243212,"about_ca_system_score_gemma":0.0001044272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003772824,"about_ca_topic_score_gemma":0.0002398645,"domain_scores_codex":[0.9998819,0.00002356567,0.000009139392,0.00002009655,0.00003601383,0.00002922637],"domain_scores_gemma":[0.999798,0.00004712035,0.00007704744,0.0000166295,0.00003448654,0.00002688993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001111194,0.000008851886,0.0001652045,0.00003335523,0.000005849747,0.00003862841,0.00001654366,0.00009206802,0.9989671,0.00008278165,0.0000114288,0.0004671883],"study_design_scores_gemma":[0.000006105828,0.00007805783,0.001881924,0.000003959573,0.000004796963,0.00008735703,0.00001514524,0.000637266,0.9969536,0.00004931551,0.0002782199,0.000004423517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964597,0.0008018266,0.001736523,0.00004831143,0.000006796193,0.00001437359,0.0001493649,0.00001958927,0.0007635148],"genre_scores_gemma":[0.998233,0.0004418969,0.0007599328,0.00002642257,0.000002223649,0.0000143364,0.0001721282,0.000006915858,0.0003430893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007852846,"threshold_uncertainty_score":0.002627075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003396185692786753,"score_gpt":0.2320884878142843,"score_spread":0.2286923021214976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}