{"id":"W4408244851","doi":"10.1001/jamacardio.2025.0025","title":"Finerenone for Heart Failure and Risk Estimated by the PREDICT-HFpEF Model","year":2025,"lang":"en","type":"article","venue":"JAMA Cardiology","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Women's College Hospital","funders":"","keywords":"Medicine; Heart failure; Internal medicine; Ejection fraction; Placebo; Heart failure with preserved ejection fraction; Cardiology; Randomized controlled trial; Framingham Risk Score; Cause of death; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000266409,0.0001343071,0.0003772223,0.00005704908,0.0001265383,0.00001682559,0.0000520016,0.0001424665,0.000008556302],"category_scores_gemma":[0.0001521162,0.00008341376,0.0001009721,0.00008876831,0.0001001765,0.00003052778,0.00006346078,0.0001496039,0.000007964374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003027262,"about_ca_system_score_gemma":0.00005078076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005327697,"about_ca_topic_score_gemma":0.0000160829,"domain_scores_codex":[0.9992191,0.00006597039,0.0001552516,0.0002539563,0.00006597293,0.000239799],"domain_scores_gemma":[0.9993904,0.0001858991,0.00002626504,0.0002835703,0.00005671362,0.00005715244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001666882,0.00002480663,0.03075634,0.00004945145,0.0005678202,0.000005284538,0.00003562488,0.000392676,0.0004656094,0.0009382966,0.9612579,0.005339475],"study_design_scores_gemma":[0.004942345,0.0003898123,0.01686144,0.00004904901,0.001160445,0.00005433859,0.00009766733,0.04264981,0.0002571092,0.001231078,0.9321824,0.0001244592],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6435105,0.004756478,0.1005653,0.2342502,0.0004444998,0.004805991,0.0004464671,0.0004158322,0.01080482],"genre_scores_gemma":[0.9772825,0.0003474999,0.01095017,0.002161533,0.0001683544,0.0004268433,0.0001884844,0.00001865201,0.008455932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3337721,"threshold_uncertainty_score":0.3401515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339435804481197,"score_gpt":0.2782913038406453,"score_spread":0.2648969457958333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}