{"id":"W4408246386","doi":"10.1038/d41586-025-00546-w","title":"Designer cannabinoids could be the key to pain relief without adverse effects","year":2025,"lang":"en","type":"article","venue":"Nature","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Key (lock); Adverse effect; Pain relief; Medicine; Business; Pharmacology; Internet privacy; Anesthesia; Computer science; Computer security","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005062331,0.0005168299,0.0005000393,0.0004963666,0.0006215638,0.001524228,0.0007081975,0.00145283,0.02145476],"category_scores_gemma":[0.001119024,0.0002018411,0.000397013,0.0002631934,0.001097457,0.001413249,0.0006446135,0.002116635,0.003046612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000790187,"about_ca_system_score_gemma":0.000978909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001464329,"about_ca_topic_score_gemma":0.003325387,"domain_scores_codex":[0.9997711,0.00003978741,0.00001283581,0.00003860935,0.00009487185,0.00004281915],"domain_scores_gemma":[0.9996501,0.0001002329,0.00006149661,0.0000380457,0.00008777494,0.00006230274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003311936,0.0006032294,0.001581436,0.005083381,0.0002256996,0.001191744,0.0002111323,0.0004920464,0.2129474,0.1895707,0.03529093,0.5494903],"study_design_scores_gemma":[0.0004514663,0.001763244,0.005976199,0.001451042,0.0002785793,0.003460931,0.0003146747,0.0005201123,0.08200452,0.08348411,0.8201778,0.0001174316],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.06621105,0.5831294,0.02400573,0.07539766,0.01514939,0.0002837049,0.00139099,0.0005606111,0.2338715],"genre_scores_gemma":[0.5346791,0.3080307,0.01463712,0.02429928,0.005763687,0.0002216993,0.0006358866,0.0001198564,0.1116127],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02145476,"threshold_uncertainty_score":0.07177329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007212914360874003,"score_gpt":0.3061764268559895,"score_spread":0.2989635124951155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}