{"id":"W4408246949","doi":"10.1038/s41467-025-57453-x","title":"Salmonella exploits LRRK2-dependent plasma membrane dynamics to invade host cells","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; SickKids Foundation; University of Saskatchewan; Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Natural Sciences and Engineering Research Council of Canada; Leona M. and Harry B. Helmsley Charitable Trust; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Host (biology); Salmonella; Dynamics (music); Exploit; Biology; Microbiology; Bacteria; Computer science; Genetics; Physics; Computer security","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001231643,0.0003794848,0.0001984694,0.0001143747,0.0001119285,0.0002318477,0.0001568618,0.0003480602,0.0006657508],"category_scores_gemma":[0.00008730588,0.0001498591,0.000226155,0.00005779163,0.0001998263,0.0002760066,0.0004172022,0.0004712413,0.0004778126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003236067,"about_ca_system_score_gemma":0.0001100413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002496325,"about_ca_topic_score_gemma":0.0005108178,"domain_scores_codex":[0.999885,0.00001506372,0.000008319347,0.00002285948,0.0000372075,0.00003155833],"domain_scores_gemma":[0.9999253,0.000008703965,0.00003005181,0.00001228806,0.000007908613,0.00001583001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003139663,0.000004443932,0.0001558854,0.00001653803,0.000002199369,0.00007150172,0.000004167841,0.00005278646,0.9990971,0.00007680912,0.00003263644,0.0004545652],"study_design_scores_gemma":[0.00001381688,0.0001336841,0.005643507,0.000005011668,0.000006727036,0.000902577,0.00002425095,0.001903817,0.9895071,0.00008192761,0.001770567,0.000006982154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916492,0.001498105,0.004227966,0.0002726755,0.00003383344,0.00001809668,0.0001813273,0.0001654768,0.001953461],"genre_scores_gemma":[0.9960541,0.000487614,0.001759468,0.00006606345,0.000006840553,0.00001836683,0.0002077396,0.0000180265,0.001381772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006657508,"threshold_uncertainty_score":0.002347946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008685474531597384,"score_gpt":0.261756805458648,"score_spread":0.2530713309270506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}