{"id":"W4408248400","doi":"10.2196/preprints.73039","title":"Effectiveness of Tocotrienol-Rich Fraction in Older Adults: Protocol for a Randomized, Double-Blind, Placebo-Controlled Trial (Preprint)","year":2025,"lang":"en","type":"preprint","venue":"","topic":"Antioxidant Activity and Oxidative Stress","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Placebo; Medicine; Internal medicine; Vitamin E; Clinical trial; Clinical endpoint; Tocotrienol; Physical therapy; Antioxidant; Tocopherol; Pathology; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01741985,0.005455726,0.01113285,0.001819526,0.003064584,0.003382142,0.002997739,0.007217711,0.0660441],"category_scores_gemma":[0.0168618,0.002810749,0.005539613,0.002375136,0.002760196,0.003425242,0.001619424,0.00699817,0.01142088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003778307,"about_ca_system_score_gemma":0.01083951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002019089,"about_ca_topic_score_gemma":0.004476544,"domain_scores_codex":[0.9905453,0.004846606,0.001325259,0.001153345,0.001033388,0.001096173],"domain_scores_gemma":[0.9931117,0.001369113,0.001713002,0.0008973388,0.001725211,0.001183722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.947033,0.01025146,0.0003646114,0.01284552,0.001557496,0.000114596,0.0001452357,0.0007269373,0.001911189,0.001383158,0.009334385,0.01433243],"study_design_scores_gemma":[0.9635478,0.01846395,0.001121329,0.001497177,0.0006961575,0.00003037589,0.00005044872,0.0006914712,0.0004166422,0.0008398407,0.01258956,0.00005511738],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.002710034,0.0004592128,0.0008246871,0.0002396391,0.0005091474,0.993443,0.001080886,0.0001057863,0.0006274633],"genre_scores_gemma":[0.003265154,0.0002672423,0.001465907,0.0002789863,0.0001118822,0.9938481,0.000219644,0.000006140284,0.0005367769],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0660441,"threshold_uncertainty_score":0.2209395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02574399476375883,"score_gpt":0.3625625120576984,"score_spread":0.3368185172939396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}