{"id":"W4408279374","doi":"10.1073/pnas.2424470122","title":"Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranes","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; National Institutes of Health; Canada Research Chairs; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Hospital for Sick Children; University of Virginia","keywords":"Chemistry; Phosphorylation; Cystic fibrosis transmembrane conductance regulator; Intracellular; Cell biology; Chloride channel; Membrane protein; Calcium; Calmodulin; Biophysics; Biochemistry; Membrane; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008088367,0.0001704528,0.000206295,0.0001083403,0.0003264977,0.0003752377,0.0002062859,0.000210717,0.000901625],"category_scores_gemma":[0.0002047086,0.0001397641,0.0001759347,0.00009892852,0.0003539133,0.0002789419,0.0003112084,0.00032062,0.0001573522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005788777,"about_ca_system_score_gemma":0.0003418361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002177014,"about_ca_topic_score_gemma":0.002161934,"domain_scores_codex":[0.9999342,0.000009242106,0.000002845454,0.00001146014,0.00001771636,0.00002450261],"domain_scores_gemma":[0.9999464,0.00001599714,0.00001328754,0.000003518038,0.000005994752,0.00001499213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002150395,0.00007429694,0.001530999,0.00006778659,0.00002051726,0.0001106625,0.00005767471,0.01173233,0.9825969,0.001338133,0.000250945,0.002004683],"study_design_scores_gemma":[0.0001215252,0.0002561854,0.01658186,0.00002252764,0.00004605361,0.0001452004,0.0002943946,0.2575678,0.7217756,0.001291967,0.001852755,0.00004412932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998069,0.0001366573,0.0007318662,0.00008052739,0.000008530713,0.000006560389,0.0000291763,0.00001880405,0.000918819],"genre_scores_gemma":[0.9993712,0.0001186891,0.0003229848,0.00001626521,0.00000165365,0.000005388033,0.00002669663,0.000005237103,0.0001318825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002177014,"threshold_uncertainty_score":0.004328668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03511175228896084,"score_gpt":0.3534920028968391,"score_spread":0.3183802506078782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}