{"id":"W4408279621","doi":"10.1101/2025.03.07.641990","title":"Pregnenolone and AEF0117 block cannabinoid-induced hyperlocomotion through GSK3β signaling at striatopallidal neurons","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Striatum; Neuroscience; Cannabinoid; Pharmacology; Endocannabinoid system; Protein kinase B; Signal transduction; Chemistry; Biology; Medicine; Internal medicine; Cell biology; Dopamine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006707414,0.0002375372,0.0001833281,0.0002165608,0.0001468852,0.0001780656,0.0001673553,0.0001643578,0.004410647],"category_scores_gemma":[0.00005216708,0.00008643739,0.000205153,0.0001300682,0.0002169659,0.0001194101,0.0001314263,0.0004514288,0.0006469073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002214614,"about_ca_system_score_gemma":0.00033248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001091417,"about_ca_topic_score_gemma":0.002195675,"domain_scores_codex":[0.9999577,0.000004641123,0.000004386155,0.000006567034,0.000009371696,0.00001729881],"domain_scores_gemma":[0.999982,0.000002416463,0.000004875467,0.000002206241,0.000001862347,0.00000663862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008530569,0.00009518975,0.0001849964,0.0001304789,0.00001259811,0.000139856,0.0000276551,0.0001041381,0.9937687,0.0003351494,0.0002381904,0.004109959],"study_design_scores_gemma":[0.0001190041,0.0005225093,0.00418205,0.00001306418,0.00001526862,0.0002040724,0.00003971195,0.0007015525,0.9905005,0.0001390007,0.003558713,0.000004655094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98956,0.00233616,0.001364345,0.0003401418,0.00006578162,0.00004495536,0.0009608574,0.0001255441,0.005202075],"genre_scores_gemma":[0.9837238,0.00218222,0.00237682,0.00009462146,0.00001337132,0.00006613017,0.0009335757,0.00002592324,0.01058351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004410647,"threshold_uncertainty_score":0.01475513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02438755127818878,"score_gpt":0.2660013893639224,"score_spread":0.2416138380857336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}