{"id":"W4408283791","doi":"10.1016/j.bios.2025.117368","title":"Nano biosensor unlocks tumor derived immune signals for the early detection of ovarian cancer","year":2025,"lang":"en","type":"article","venue":"Biosensors and Bioelectronics","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; St. Michael's Hospital","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Ovarian cancer; Immune system; Biosensor; Cancer detection; Nano-; Cancer; Cancer research; Medicine; Biology; Oncology; Nanotechnology; Materials science; Internal medicine; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002805222,0.0002242457,0.0003428836,0.0001210165,0.0003788056,0.00002222048,0.0002280994,0.0002428676,0.00004718097],"category_scores_gemma":[0.00006568181,0.0001586346,0.0001540251,0.0002860103,0.0003848691,0.0000365439,0.0000701344,0.0002437321,0.000006324338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008687128,"about_ca_system_score_gemma":0.0001817969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006146132,"about_ca_topic_score_gemma":0.000139289,"domain_scores_codex":[0.9986697,0.0001010431,0.0003920781,0.00031743,0.00003533639,0.0004844183],"domain_scores_gemma":[0.998957,0.0003372292,0.0002074873,0.0003205549,0.0001657813,0.00001191198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005247298,0.00004196497,0.0000944429,0.00004927199,0.0004048398,2.84879e-7,0.000097063,0.000006697758,0.9785707,0.000604251,0.0002711623,0.01933462],"study_design_scores_gemma":[0.001301881,0.0003795528,0.00208069,0.00005199465,0.0001803587,0.000008616583,0.0001157454,0.00004144883,0.9386199,0.0001542424,0.05689296,0.0001726768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9084616,0.08746847,0.0008034359,0.0009291015,0.001284851,0.0008181062,0.00007811953,0.00004981745,0.0001064726],"genre_scores_gemma":[0.994015,0.002899918,0.00006415657,0.0002112341,0.00003562118,0.00009676529,0.00001008363,0.00002019334,0.002647034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08555336,"threshold_uncertainty_score":0.6468933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00842427445787887,"score_gpt":0.2416961350037792,"score_spread":0.2332718605459003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}