{"id":"W4408284674","doi":"10.1016/j.jbc.2025.108398","title":"Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes","year":2025,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; University of British Columbia; Canadian Institutes of Health Research; Genome British Columbia; Canada Foundation for Innovation","keywords":"Pyruvate dehydrogenase kinase; Biochemistry; Pyruvate kinase; Pyruvate decarboxylation; Pyruvate dehydrogenase complex; Chemistry; Glycerol kinase; Pyruvate dehydrogenase phosphatase; Hydrolysis; Dehydrogenase; Enzyme; Glycolysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893329,0.0003845409,0.0002952576,0.0002311694,0.0002158177,0.0005703633,0.0002611166,0.0003038421,0.001275921],"category_scores_gemma":[0.0001946338,0.0002863923,0.0002823537,0.0001940926,0.0002565183,0.0003211253,0.0003121322,0.0006946689,0.0006838604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005665325,"about_ca_system_score_gemma":0.0002796972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000543757,"about_ca_topic_score_gemma":0.0006520703,"domain_scores_codex":[0.9997053,0.00002516048,0.00003787948,0.0001178963,0.00005492862,0.00005878757],"domain_scores_gemma":[0.9998577,0.0000137277,0.00004903773,0.00002178281,0.00002026301,0.00003751247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001847633,0.00001857672,0.0005934393,0.00005277234,0.000006107089,0.00003209568,0.0000123058,0.00006331105,0.9977113,0.0000945031,0.00007231542,0.001158654],"study_design_scores_gemma":[0.00003207069,0.0001320823,0.01369201,0.000009473355,0.00002212967,0.0001595505,0.00003614343,0.001152802,0.9818211,0.00007759003,0.002857363,0.000007767342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825351,0.00480712,0.007788756,0.0003085593,0.0002334421,0.00005796287,0.001882906,0.0002121282,0.002173947],"genre_scores_gemma":[0.9894777,0.001778253,0.002500484,0.0001277052,0.00002209192,0.00006451413,0.001393952,0.00004947649,0.004585911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001275921,"threshold_uncertainty_score":0.004268408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354628370105149,"score_gpt":0.2797302092253978,"score_spread":0.2661839255243463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}