{"id":"W4408287567","doi":"10.1021/acs.jmedchem.4c02021","title":"Monoselective Histone Deacetylase 6 PROTAC Degrader Shows <i>In Vivo</i> Tractability","year":2025,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canada Research Chairs; Leukemia and Lymphoma Society of Canada; Cancer Research Society","keywords":"Chemistry; In vivo; Histone deacetylase; Histone; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001884507,0.0005461883,0.0002595757,0.0001577115,0.0001253523,0.000403266,0.0002929849,0.0003151063,0.001290624],"category_scores_gemma":[0.0001244765,0.000152888,0.0003574677,0.0001014113,0.0001433663,0.0001607312,0.0001329525,0.0004932144,0.0009041969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003097813,"about_ca_system_score_gemma":0.0001939112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004061692,"about_ca_topic_score_gemma":0.0007346345,"domain_scores_codex":[0.9998205,0.00002525985,0.00001522222,0.00003514435,0.00007186417,0.00003202314],"domain_scores_gemma":[0.9998645,0.00001246868,0.00005479765,0.00001891551,0.00002031983,0.00002909382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000141492,0.00004058954,0.0001190077,0.00004358366,0.00001045763,0.00003627073,0.000004769496,0.0001203418,0.9964885,0.00009215913,0.0001502883,0.002752686],"study_design_scores_gemma":[0.000008831115,0.000254331,0.0002530988,0.00000156168,0.00001137062,0.0002384196,0.000002935509,0.0002376742,0.9961952,0.00001287385,0.002781617,0.000002109095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9442905,0.004892659,0.03926843,0.0003684519,0.0001410941,0.0001891388,0.00206173,0.0007650736,0.008022981],"genre_scores_gemma":[0.9747071,0.001831426,0.01422005,0.0001566372,0.00002894353,0.00007593862,0.002336301,0.0001145932,0.006528999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001290624,"threshold_uncertainty_score":0.004317582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005656923900489274,"score_gpt":0.2786706986850257,"score_spread":0.2730137747845364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}