{"id":"W4408296594","doi":"10.1158/1535-7163.mct-24-0656","title":"5′- <i>S</i> -(3-Aminophenyl)-5′-thioadenosine, a Novel Chemoprotective Agent for Reducing Toxic Side Effects of Fluorouracil in Treatment of MTAP-Deficient Cancers","year":2025,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; BC Cancer Agency; Ontario Institute for Cancer Research; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research; Terry Fox Research Institute; Lotte and John Hecht Memorial Foundation; U.S. Department of Defense","keywords":"Toxicity; Pharmacology; Cytotoxicity; Chemistry; Cancer cell; Cancer research; Cancer; Biochemistry; Medicine; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001117059,0.0002732135,0.0003972773,0.0001252081,0.00004094945,0.00001031961,0.0002444038,0.0002276882,0.000002065124],"category_scores_gemma":[0.00004808672,0.0002559871,0.0002603108,0.0003537415,0.000157107,0.000002897184,0.00008721517,0.00009844494,2.382079e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003100938,"about_ca_system_score_gemma":0.0004712536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000595392,"about_ca_topic_score_gemma":0.00007537421,"domain_scores_codex":[0.9984106,0.00005832079,0.0003846805,0.0005149454,0.0002261093,0.000405277],"domain_scores_gemma":[0.9990882,0.00003953191,0.0001459862,0.0004616671,0.0002112385,0.00005337771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004462865,0.0004979519,0.0001054616,0.0004668857,0.0004083979,0.000004473626,0.0001715956,0.000885221,0.9783906,0.000108183,0.00002313662,0.01849182],"study_design_scores_gemma":[0.002745546,0.0008114994,0.0003038124,0.0002364585,0.0001300415,0.000001556161,0.0000647761,0.0003180942,0.9906528,0.0001000545,0.004420143,0.0002152344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9453421,0.02607478,0.02585733,0.0003450669,0.0001854323,0.001635318,0.00007683647,0.000008962113,0.0004742282],"genre_scores_gemma":[0.9960364,0.001196104,0.001257592,0.0004923942,0.0000350166,0.0006697784,0.00003907069,0.00003643755,0.0002371883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05069437,"threshold_uncertainty_score":0.9999892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01935784453817129,"score_gpt":0.3081458575001949,"score_spread":0.2887880129620236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}