{"id":"W4408296594","doi":"10.1158/1535-7163.mct-24-0656","title":"5′- <i>S</i> -(3-Aminophenyl)-5′-thioadenosine, a Novel Chemoprotective Agent for Reducing Toxic Side Effects of Fluorouracil in Treatment of MTAP-Deficient Cancers","year":2025,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; BC Cancer Agency; Ontario Institute for Cancer Research; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"National Cancer Institute; Canadian Institutes of Health Research; Terry Fox Research Institute; Lotte and John Hecht Memorial Foundation; U.S. Department of Defense","keywords":"Toxicity; Pharmacology; Cytotoxicity; Chemistry; Cancer cell; Cancer research; Cancer; Biochemistry; Medicine; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169567,0.0003671434,0.0002295658,0.0001916484,0.0001351544,0.0001660925,0.0001978215,0.0002873597,0.0006606656],"category_scores_gemma":[0.00009161903,0.0001435277,0.0002581966,0.0001740738,0.0001140326,0.0001793651,0.0001437747,0.000335167,0.0002551796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001440208,"about_ca_system_score_gemma":0.0001459893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003357218,"about_ca_topic_score_gemma":0.0006228805,"domain_scores_codex":[0.9999133,0.00001472522,0.000007102502,0.00002534269,0.00002300353,0.00001642968],"domain_scores_gemma":[0.999952,0.000008283936,0.00001609682,0.000005120897,0.000006542898,0.00001197554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004975881,0.00001877084,0.0001108381,0.00005494216,0.000003756846,0.00005479857,0.000008486239,0.0001461072,0.9969599,0.00006772569,0.00002271189,0.002502089],"study_design_scores_gemma":[0.00001011643,0.000593858,0.001170619,0.000004434978,0.00001547248,0.0003295532,0.000007791843,0.0005027789,0.9945,0.00002449303,0.00283581,0.000004933563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774051,0.007631634,0.01035453,0.0001010215,0.00003118961,0.00009393392,0.0003632989,0.0001523739,0.003866857],"genre_scores_gemma":[0.9871133,0.002693101,0.008017505,0.0000583979,0.00001254318,0.00004832297,0.0004295584,0.00001441405,0.001612777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006606656,"threshold_uncertainty_score":0.00221014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01935784453817129,"score_gpt":0.3081458575001949,"score_spread":0.2887880129620236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}