{"id":"W4408300332","doi":"10.1021/acschemneuro.4c00866","title":"Radiosynthesis, <i>In Vitro</i> Characterization, and <i>In Vivo</i> PET Neuroimaging of [<sup>18</sup>F]F-4 for Tau Protein: A First-in-Human PET Study","year":2025,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Aging; Tau Consortium; Canada Research Chairs; Canada Foundation for Innovation; Ontario Research Foundation; Azrieli Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Positron emission tomography; Progressive supranuclear palsy; Radiosynthesis; In vivo; Neuroimaging; Corticobasal degeneration; Molecular imaging; Pet imaging; Preclinical imaging; Human brain; Blood–brain barrier; Pittsburgh compound B; In vitro; Chemistry; Translocator protein; Radioligand; Nuclear medicine; Neuroscience; Pathology; Medicine; Alzheimer's disease; Psychology; Biochemistry; Neuroinflammation; Disease; Central nervous system; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002457172,0.0001962781,0.0004088865,0.0002683108,0.00007583365,0.00003601367,0.0002295638,0.00002492152,0.000006310853],"category_scores_gemma":[0.0005705903,0.0001801223,0.00005027536,0.0007825107,0.0002414009,0.0001959174,0.0001386884,0.0001901718,5.31702e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006030189,"about_ca_system_score_gemma":0.0001355794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004069646,"about_ca_topic_score_gemma":0.000005056715,"domain_scores_codex":[0.9980414,0.00006760782,0.0004094233,0.0006686561,0.0003449756,0.0004679721],"domain_scores_gemma":[0.9992402,0.0001706311,0.00006979787,0.0003232073,0.00005426145,0.0001419296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005220653,0.00172608,0.07270136,0.0001819249,0.00001945486,0.0003243466,0.00007679654,0.000003716016,0.9242281,0.00001898088,0.00002464716,0.0001725403],"study_design_scores_gemma":[0.007788255,0.000400011,0.09305459,0.0004472776,0.0001000429,0.00005405243,0.0001137979,0.005468895,0.8919594,0.0001289771,0.0002147818,0.0002698971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965208,0.00008845287,0.00001692566,0.001008717,0.00001775552,0.002193031,0.00004941731,0.00002124213,0.00008370507],"genre_scores_gemma":[0.999058,0.00003369317,0.00008000349,0.0003777875,0.00001442331,0.0003478887,0.00001332033,0.00001706902,0.0000578191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03226866,"threshold_uncertainty_score":0.7345174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01915173856338511,"score_gpt":0.3002519804744504,"score_spread":0.2811002419110653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}