{"id":"W4408300332","doi":"10.1021/acschemneuro.4c00866","title":"Radiosynthesis, <i>In Vitro</i> Characterization, and <i>In Vivo</i> PET Neuroimaging of [<sup>18</sup>F]F-4 for Tau Protein: A First-in-Human PET Study","year":2025,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Aging; Tau Consortium; Canada Research Chairs; Canada Foundation for Innovation; Ontario Research Foundation; Azrieli Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Positron emission tomography; Progressive supranuclear palsy; Radiosynthesis; In vivo; Neuroimaging; Corticobasal degeneration; Molecular imaging; Pet imaging; Preclinical imaging; Human brain; Blood–brain barrier; Pittsburgh compound B; In vitro; Chemistry; Translocator protein; Radioligand; Nuclear medicine; Neuroscience; Pathology; Medicine; Alzheimer's disease; Psychology; Biochemistry; Neuroinflammation; Disease; Central nervous system; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003873759,0.0005220974,0.0002146283,0.0002308357,0.0002311544,0.0002847475,0.0003463817,0.0004655458,0.001667733],"category_scores_gemma":[0.0003604581,0.0002899639,0.0002888985,0.0001432402,0.0003227878,0.0002709781,0.0001160663,0.0003598924,0.0006718865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003658881,"about_ca_system_score_gemma":0.000219915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002522127,"about_ca_topic_score_gemma":0.001550856,"domain_scores_codex":[0.9998943,0.00003788126,0.000003723044,0.00002796203,0.00001513052,0.00002109383],"domain_scores_gemma":[0.9998719,0.00003578437,0.00003210181,0.00001509353,0.00002838958,0.00001686468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0005144707,0.0001052736,0.0003161817,0.00008179534,0.00001663476,0.00017791,0.00006387298,0.0005815138,0.9947069,0.0001127701,0.0001634785,0.003159125],"study_design_scores_gemma":[0.00003664318,0.002019142,0.002877015,0.000007439432,0.00006070338,0.00106349,0.00009160161,0.00185294,0.988291,0.00006781523,0.003615105,0.00001711258],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778191,0.003380348,0.01273191,0.0001987789,0.00002214697,0.0001337099,0.0004237897,0.000110251,0.005180052],"genre_scores_gemma":[0.9806072,0.003064591,0.01000572,0.0001199046,0.00002582386,0.00007098038,0.000677663,0.00009119105,0.005336909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002522127,"threshold_uncertainty_score":0.005579114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01915173856338511,"score_gpt":0.3002519804744504,"score_spread":0.2811002419110653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}