{"id":"W4408301389","doi":"10.1111/imm.13916","title":"Original Antigenic Sin in <scp>CD4</scp>+ T Cells","year":2025,"lang":"en","type":"article","venue":"Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"China Scholarship Council; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Canadian Institutes of Health Research; Natural Science Foundation of Shanghai","keywords":"Antigen; Heterologous; Immunology; Immune system; T cell; Acquired immune system; Biology; Antibody; Memory T cell; Immunity; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001512602,0.0002449235,0.0002362851,0.0001583969,0.0002335597,0.0005360426,0.0002312814,0.0004170591,0.00258577],"category_scores_gemma":[0.0003214261,0.0001378822,0.0002774632,0.0001867918,0.0005179723,0.0004264033,0.0002532191,0.0003787119,0.0003626205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004668093,"about_ca_system_score_gemma":0.0004873356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001341737,"about_ca_topic_score_gemma":0.0009070116,"domain_scores_codex":[0.9999014,0.00002152705,0.000004023139,0.00002165209,0.00002912119,0.00002224851],"domain_scores_gemma":[0.9999026,0.00002833462,0.00003218332,0.0000103811,0.00001108944,0.00001540432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005041562,0.0001953892,0.009617918,0.0003567295,0.00005598967,0.002383781,0.0002030134,0.4628257,0.3799146,0.1152603,0.003670319,0.02501224],"study_design_scores_gemma":[0.00008343357,0.0003377243,0.004724632,0.00002730522,0.0000332786,0.0007253346,0.00007764235,0.9052761,0.04066103,0.03909495,0.008935076,0.00002356575],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9016554,0.0009331483,0.07017068,0.000644375,0.0002038052,0.000041822,0.0001927242,0.0002862161,0.02587185],"genre_scores_gemma":[0.9936821,0.0001698465,0.002222095,0.00007521198,0.0000162267,0.00001380551,0.00004824979,0.00002057841,0.003751887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00258577,"threshold_uncertainty_score":0.008650243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007610746058220685,"score_gpt":0.2317514978361005,"score_spread":0.2241407517778798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}