{"id":"W4408301389","doi":"10.1111/imm.13916","title":"Original Antigenic Sin in <scp>CD4</scp>+ T Cells","year":2025,"lang":"en","type":"article","venue":"Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"China Scholarship Council; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Canadian Institutes of Health Research; Natural Science Foundation of Shanghai","keywords":"Antigen; Heterologous; Immunology; Immune system; T cell; Acquired immune system; Biology; Antibody; Memory T cell; Immunity; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003681262,0.0004682619,0.0008222196,0.0008379224,0.00027601,0.00002560018,0.0009162432,0.001148147,0.0007727754],"category_scores_gemma":[0.0001858708,0.0004576593,0.000217326,0.0008014114,0.0009365348,0.0001321077,0.0003796048,0.001253451,0.00604704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001536937,"about_ca_system_score_gemma":0.0003081208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005231451,"about_ca_topic_score_gemma":0.0002091171,"domain_scores_codex":[0.996499,0.000595424,0.0007752331,0.0007914145,0.00003998406,0.001298925],"domain_scores_gemma":[0.9980643,0.0007771773,0.0001974816,0.0008415121,0.00009738738,0.00002214797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009947646,0.0004486876,0.004815179,0.00002162271,0.000445834,0.00005831411,0.000336046,0.00000771029,0.968599,0.0083108,0.01256524,0.004292082],"study_design_scores_gemma":[0.002458915,0.0002065943,0.004363089,0.00003971975,0.00004424091,0.0000909462,0.000517519,0.000002250834,0.5495529,0.001075614,0.4415176,0.0001305953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.945949,0.02927336,0.0001743892,0.00059394,0.006218879,0.0003935088,0.00002114619,0.000240018,0.01713583],"genre_scores_gemma":[0.9577265,0.001428284,0.0001193281,0.0005691135,0.00004080282,0.00006903975,0.00009706684,0.00003317487,0.03991669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4289523,"threshold_uncertainty_score":0.9997875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007610746058220685,"score_gpt":0.2317514978361005,"score_spread":0.2241407517778798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}