{"id":"W4408301502","doi":"10.1002/mco2.70127","title":"Colorectal Cancer: Pathogenesis and Targeted Therapy","year":2025,"lang":"en","type":"review","venue":"MedComm","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Shanghai Rising-Star Program; National Natural Science Foundation of China","keywords":"Epigenetics; Reprogramming; Crosstalk; Biology; Epigenesis; Cell metabolism; Colorectal cancer; Bioinformatics; DNA methylation; Cancer; Epigenetic therapy; Cancer research; Epigenomics; Genetics; Gene; Cell; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003583137,0.000661236,0.0008295655,0.001328019,0.0002737344,0.0007944612,0.0007386689,0.0009799289,0.003793387],"category_scores_gemma":[0.0005515497,0.0001647348,0.0003602008,0.0009119783,0.0004794471,0.0008461472,0.0006795835,0.002007924,0.001866794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007951875,"about_ca_system_score_gemma":0.0008175331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001052231,"about_ca_topic_score_gemma":0.002224861,"domain_scores_codex":[0.9998435,0.00003322093,0.00001478904,0.00002720282,0.00005843965,0.00002286636],"domain_scores_gemma":[0.9998333,0.00005631457,0.00002211728,0.000008404337,0.00005018835,0.00002959478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007884845,0.00005647133,0.0001788438,0.008017084,0.00006046933,0.0002141384,0.00004312038,0.0004749278,0.002031899,0.006641222,0.07122545,0.9109775],"study_design_scores_gemma":[0.00001208621,0.00007813361,0.0005388243,0.001514956,0.00003366894,0.00079145,0.00002811313,0.0001027235,0.0003692892,0.002377667,0.9941428,0.00001022514],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001323003,0.9967996,0.0001628158,0.000999347,0.0004723661,0.000004884555,0.0000211345,0.00001421945,0.001393243],"genre_scores_gemma":[0.001383,0.9961293,0.0001910551,0.0005245853,0.0004107422,0.000008348842,0.00004669008,0.000002280508,0.001304015],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003793387,"threshold_uncertainty_score":0.01269013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708360762411372,"score_gpt":0.3048003001090041,"score_spread":0.2877166924848904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}