{"id":"W4408301502","doi":"10.1002/mco2.70127","title":"Colorectal Cancer: Pathogenesis and Targeted Therapy","year":2025,"lang":"en","type":"review","venue":"MedComm","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Shanghai Rising-Star Program; National Natural Science Foundation of China","keywords":"Epigenetics; Reprogramming; Crosstalk; Biology; Epigenesis; Cell metabolism; Colorectal cancer; Bioinformatics; DNA methylation; Cancer; Epigenetic therapy; Cancer research; Epigenomics; Genetics; Gene; Cell; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001415664,0.0003722839,0.0009395267,0.00008151874,0.00008526215,0.00002689258,0.000259938,0.0004212736,0.00004762096],"category_scores_gemma":[0.00004193172,0.000303574,0.0003234924,0.0001612984,0.00009652194,0.000001436918,0.0001507523,0.0001515534,0.000003603589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001964858,"about_ca_system_score_gemma":0.0005120388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005800855,"about_ca_topic_score_gemma":0.00008101023,"domain_scores_codex":[0.9986886,0.0001564484,0.0002821475,0.0004997169,0.0001026771,0.0002704443],"domain_scores_gemma":[0.9993392,0.00002862578,0.0001383325,0.0003465732,0.00005103405,0.00009618235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001641609,0.00002177738,0.00001222512,0.001533392,0.0001944933,9.049037e-7,0.00001187969,1.131573e-7,0.001298323,0.000009340378,0.007472091,0.9894291],"study_design_scores_gemma":[0.000291984,0.000063334,0.00004270258,0.0007397546,0.0002545968,0.00001167369,0.000004228747,2.643155e-7,0.0007290295,0.000005239765,0.9975404,0.0003167622],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004073736,0.9964759,0.0000162811,0.00002383906,0.001754614,0.0005373704,0.0003553064,0.00001816147,0.0004111889],"genre_scores_gemma":[0.00001842641,0.9953277,0.0000807309,0.0001723909,0.001664553,0.0004241077,0.0004458094,0.00004431784,0.001822032],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9900683,"threshold_uncertainty_score":0.9999416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01708360762411372,"score_gpt":0.3048003001090041,"score_spread":0.2877166924848904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}