{"id":"W4408301578","doi":"10.1002/mds.30162","title":"Update on Treatments for Parkinson's Disease Motor Fluctuations – An International Parkinson and Movement Disorder Society Evidence‐Based Medicine Review","year":2025,"lang":"en","type":"review","venue":"Movement Disorders","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Calgary; Ottawa Hospital; Toronto Western Hospital; University of Ottawa","funders":"Dystonia Coalition; Parkinsonfonden; National Institutes of Health; AOP Orphan; Canadian Institutes of Health Research; Ipsen; H. Lundbeck A/S; Stichting ParkinsonFonds; University of California, San Diego; University of Toronto; Parkinson Canada; GW Pharmaceuticals; Michael J. Fox Foundation for Parkinson's Research; Boston Scientific Corporation; Allergan; International Parkinson and Movement Disorder Society; Pfizer; Biogen; Parkinson's Foundation; Novartis; CurePSP; Medical Research Council; Teva Pharmaceutical Industries; Fondation Brain Canada; Eisai; University of Oxford; Parkinson's UK; CHDI Foundation; Austrian Science Fund; Amsterdam Neuroscience; ZonMw","keywords":"Ropinirole; Levodopa; Pramipexole; Entacapone; Rotigotine; Medicine; Parkinson's disease; Pallidotomy; Randomized controlled trial; Dyskinesia; Deep brain stimulation; Movement disorders; Physical medicine and rehabilitation; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003210535,0.001024627,0.001969066,0.0002693699,0.0002989351,0.00005252307,0.000370646,0.0002102536,0.0004872333],"category_scores_gemma":[0.0003968388,0.0007079932,0.001056502,0.0003783204,0.0001918815,0.000204635,0.0001205656,0.0002789024,0.00001480507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003655921,"about_ca_system_score_gemma":0.0003308381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005656666,"about_ca_topic_score_gemma":0.00002401916,"domain_scores_codex":[0.9959416,0.00019577,0.001012432,0.001499267,0.0007965936,0.0005542985],"domain_scores_gemma":[0.9975017,0.0004860851,0.0004910936,0.0009309475,0.0001286081,0.000461603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003463619,0.002876226,0.001479668,0.03034827,0.001718804,0.00001434927,0.00001693045,0.000004929524,4.652895e-7,0.000519717,0.02096453,0.9417098],"study_design_scores_gemma":[0.004108864,0.002117922,0.001898289,0.0566208,0.00824818,7.238988e-8,0.00002095428,0.0002483308,2.03563e-7,0.004438031,0.9217632,0.0005351017],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004572808,0.964806,0.0004509502,0.02316892,0.0004028847,0.009873358,0.0008882805,0.0001105348,0.000253303],"genre_scores_gemma":[0.00002632818,0.9180721,0.0004468175,0.06993108,0.0001093723,0.006159531,0.003886756,0.00008123367,0.001286751],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9411746,"threshold_uncertainty_score":0.9995371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0643913048123666,"score_gpt":0.38230002472646,"score_spread":0.3179087199140934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}