{"id":"W4408316270","doi":"10.1101/2025.03.09.25323609","title":"A Multicentre Randomised Controlled Trial Assessing the Efficacy of Antimicrobial Prophylaxis for Extracorporeal Shock Wave Lithotripsy in Reducing Urinary Tract Infection (APPEAL): Statistical Analysis Plan and Methodology","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Urinary Tract Infections Management","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Centre Hospitalier Universitaire de Sherbrooke; University of Toronto; McMaster University; Impact","funders":"Sigrid Juséliuksen Säätiö; Physicians' Services Incorporated Foundation; Lawson Health Research Institute","keywords":"Medicine; Extracorporeal shock wave lithotripsy; Urinary system; Antimicrobial; Antibiotic prophylaxis; Randomized controlled trial; Lithotripsy; Surgery; Appeal; Intensive care medicine; Internal medicine; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00477151,0.0004755351,0.002437765,0.001480858,0.0001646135,0.00007879023,0.0001413669,0.000468513,0.00003779466],"category_scores_gemma":[0.005243167,0.0003512875,0.0007738329,0.0007290913,0.0002110267,0.00007885056,0.0002289454,0.001145727,3.742437e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000224139,"about_ca_system_score_gemma":0.0004035134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006634354,"about_ca_topic_score_gemma":0.00005918682,"domain_scores_codex":[0.994467,0.002211547,0.001700392,0.0009019105,0.0002984721,0.0004207412],"domain_scores_gemma":[0.9888936,0.00913606,0.0009770049,0.0006731818,0.0002088851,0.0001112114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8498964,0.01847285,0.09486366,0.003514765,0.008856694,0.0003690955,0.001581609,0.008811017,0.001482431,0.000136536,0.00007148632,0.0119434],"study_design_scores_gemma":[0.5864305,0.002854021,0.3654,0.0005633204,0.01482804,0.00009393696,0.0001016953,0.02892551,0.0002631246,0.0001245023,0.00005753702,0.0003577799],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9334965,0.000120516,0.05055254,0.0003650665,0.0008602631,0.01415669,0.00008621102,0.00006353097,0.0002986493],"genre_scores_gemma":[0.9776739,0.0001606843,0.02023182,0.00003603814,0.0002997644,0.001135759,0.0002723183,0.00003137399,0.0001582633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2705363,"threshold_uncertainty_score":0.9998939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08320153943785326,"score_gpt":0.3805936094130461,"score_spread":0.2973920699751929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}