{"id":"W4408316270","doi":"10.1101/2025.03.09.25323609","title":"A Multicentre Randomised Controlled Trial Assessing the Efficacy of Antimicrobial Prophylaxis for Extracorporeal Shock Wave Lithotripsy in Reducing Urinary Tract Infection (APPEAL): Statistical Analysis Plan and Methodology","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Urinary Tract Infections Management","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Centre Hospitalier Universitaire de Sherbrooke; University of Toronto; McMaster University; Impact","funders":"Sigrid Juséliuksen Säätiö; Physicians' Services Incorporated Foundation; Lawson Health Research Institute","keywords":"Medicine; Extracorporeal shock wave lithotripsy; Urinary system; Antimicrobial; Antibiotic prophylaxis; Randomized controlled trial; Lithotripsy; Surgery; Appeal; Intensive care medicine; Internal medicine; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1111797,0.004005285,0.008803517,0.002578727,0.001053709,0.002691552,0.002338601,0.005211457,0.01241327],"category_scores_gemma":[0.1241002,0.001380845,0.01166565,0.002459605,0.002834746,0.002388589,0.002287555,0.00259766,0.000970073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002505638,"about_ca_system_score_gemma":0.006025489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009954429,"about_ca_topic_score_gemma":0.001059311,"domain_scores_codex":[0.8597639,0.1216843,0.007332073,0.005391678,0.003778715,0.00204944],"domain_scores_gemma":[0.93007,0.0449783,0.01039264,0.007790562,0.00498401,0.001784562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9268021,0.002953256,0.004495008,0.009841482,0.02333251,0.0001241123,0.000230858,0.003100312,0.0008708043,0.002690081,0.002547703,0.0230117],"study_design_scores_gemma":[0.8989988,0.05215746,0.004439011,0.000981796,0.02039189,0.00006915953,0.0001137499,0.01449211,0.0009659341,0.004355704,0.002901055,0.0001333053],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.2319997,0.01049474,0.07383897,0.00266823,0.005337883,0.6660466,0.004816405,0.001010175,0.003787348],"genre_scores_gemma":[0.2910279,0.0008587512,0.06401128,0.001851621,0.0004037301,0.6390742,0.001013189,0.00005090645,0.001708442],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1111797,"threshold_uncertainty_score":0.5879817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08320153943785326,"score_gpt":0.3805936094130461,"score_spread":0.2973920699751929,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}