{"id":"W4408326527","doi":"10.1158/1538-7445.genfunc25-a025","title":"Abstract A025: Direct <i>in vivo</i> CRISPR screen identifies <i>BAP1</i> and <i>FAT1</i> as potent tumor suppressors in sarcomagenesis","year":2025,"lang":"en","type":"article","venue":"Cancer Research","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"CRISPR; In vivo; BAP1; Suppressor; Biology; Cancer research; Medicine; Cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003320122,0.0007688195,0.0005164005,0.0006241091,0.0003678295,0.0005476286,0.0005508389,0.0007558239,0.00515297],"category_scores_gemma":[0.0002477043,0.0002554922,0.0006788274,0.0003202745,0.0004405936,0.0002402284,0.0005263684,0.001165874,0.002148611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003901218,"about_ca_system_score_gemma":0.0003514225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001357311,"about_ca_topic_score_gemma":0.001683505,"domain_scores_codex":[0.999473,0.00004847574,0.00005663417,0.0001416649,0.0002035918,0.00007659601],"domain_scores_gemma":[0.9997068,0.00005508829,0.00008905424,0.0000403126,0.00003823978,0.00007049568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004138305,0.00002073493,0.0001368357,0.00003774893,0.000007448193,0.0000813533,0.000009772795,0.00008222683,0.9982162,0.000123536,0.0001596408,0.001082998],"study_design_scores_gemma":[0.00001466101,0.0001546871,0.001982114,0.000009973943,0.0000356327,0.000561612,0.00002019114,0.001199282,0.9892077,0.00006091037,0.006741121,0.00001215834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.902003,0.002052736,0.06452034,0.0005813491,0.0003182348,0.0005133452,0.01319315,0.004091152,0.01272661],"genre_scores_gemma":[0.9444046,0.001127529,0.02192,0.0003627263,0.00002866173,0.0002899625,0.01057921,0.0007385967,0.02054868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00515297,"threshold_uncertainty_score":0.01723838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01878287741916894,"score_gpt":0.3521488872475527,"score_spread":0.3333660098283838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}