{"id":"W4408330310","doi":"10.1245/s10434-025-17036-y","title":"Molecular KRAS ctDNA Predicts Metastases and Survival in Pancreatic Cancer: A Prospective Cohort Study","year":2025,"lang":"en","type":"article","venue":"Annals of Surgical Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Surgical oncology; Occult; KRAS; Oncology; Internal medicine; Pancreatic cancer; Stage (stratigraphy); Cohort; Cancer; Pathology; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006669,0.0003352728,0.0003533785,0.000677324,0.0005635424,0.0008150786,0.0003956908,0.0004492067,0.001685026],"category_scores_gemma":[0.001363349,0.000463188,0.0006788785,0.001136877,0.0002677941,0.0006054853,0.0005381833,0.0008421422,0.0003572898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003194243,"about_ca_system_score_gemma":0.0004161538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003997847,"about_ca_topic_score_gemma":0.005035069,"domain_scores_codex":[0.9996167,0.00006043953,0.00004257264,0.0001311411,0.00007810842,0.00007100975],"domain_scores_gemma":[0.9989027,0.0001450206,0.0003939779,0.0001662141,0.0001112073,0.000280827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001374261,0.00002189065,0.999288,0.00000348409,0.000042151,0.00005904666,0.00001805657,0.00002156975,0.0000915655,0.000005081262,0.00004658355,0.0002651436],"study_design_scores_gemma":[0.00001857487,0.0001481517,0.9988362,0.000005400635,0.00005991807,0.0004140218,0.00009971076,0.0001899683,0.00004647022,0.00001492058,0.0001622839,0.000004420541],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990597,0.0001246509,0.00005655571,0.00002207148,0.000004421779,0.000008884036,0.0005212671,0.000002501182,0.0001998608],"genre_scores_gemma":[0.9992183,0.0000870981,0.00005925939,0.00001509051,0.000006002631,0.00001040944,0.0004983784,0.000002176907,0.0001032326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003997847,"threshold_uncertainty_score":0.007949114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01873619661824135,"score_gpt":0.3392409513328131,"score_spread":0.3205047547145718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}