{"id":"W4408337415","doi":"10.1002/ajh.27655","title":"<scp><i>TP53</i></scp>‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management","year":2025,"lang":"en","type":"review","venue":"American Journal of Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Astellas Pharma; Celgene; AbbVie Canada; Kura Oncology","keywords":"Myeloid leukemia; Medicine; Venetoclax; Cancer; Oncology; Myelodysplastic syndromes; Internal medicine; Myeloid; Population; Bioinformatics; Cancer research; Immunology; Leukemia; Biology; Bone marrow","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009073504,0.0006440902,0.004054753,0.001553415,0.0001331993,0.0000563684,0.0005772436,0.0002783254,0.00009441902],"category_scores_gemma":[0.001114572,0.0004810791,0.0005445739,0.001421512,0.0007211982,0.0000775855,0.0001997211,0.002045859,0.0001712012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004013787,"about_ca_system_score_gemma":0.00124554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002446463,"about_ca_topic_score_gemma":0.000005546452,"domain_scores_codex":[0.9954634,0.0008365962,0.001805448,0.0006502054,0.0005879999,0.0006563193],"domain_scores_gemma":[0.9933015,0.002738302,0.002395571,0.00074117,0.0003644403,0.0004590081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006058475,0.0002120217,0.0004441901,0.01193872,0.002367933,0.002173224,0.00007148609,0.00000151161,2.479881e-7,0.001162559,0.1246016,0.856966],"study_design_scores_gemma":[0.0009591018,0.001196272,0.00009580484,0.0142583,0.00371518,0.008429113,0.0004409591,0.000005554282,0.00002000937,0.0001789717,0.9705387,0.0001620771],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006338411,0.9929304,0.0002077791,0.0013056,0.0004485266,0.00117193,0.00006469433,0.00003587065,0.003201349],"genre_scores_gemma":[0.0001151992,0.9946116,0.002667861,0.000612669,0.0001552967,0.0001768755,0.0000756158,0.00007911445,0.001505763],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8568039,"threshold_uncertainty_score":0.9997641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01547931291521099,"score_gpt":0.3319085732240816,"score_spread":0.3164292603088706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}