{"id":"W4408343933","doi":"10.1128/jvi.00048-25","title":"The GP2a 91/97/98 amino acid substitutions play critical roles in determining PRRSV tropism and infectivity but do not affect immune responses","year":2025,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Higher Education Discipline Innovation Project; Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of China","keywords":"Biology; Tropism; Porcine reproductive and respiratory syndrome virus; Virology; Infectivity; Tissue tropism; Arterivirus; Immune system; Virus; Genetics; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001652669,0.0003502647,0.0002185323,0.0001348536,0.0001466321,0.0002400512,0.0001441433,0.0002421682,0.001067715],"category_scores_gemma":[0.0001813028,0.00008373093,0.0003573479,0.0001231064,0.0002022549,0.0001759449,0.0001274431,0.0006621475,0.0003849537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001993574,"about_ca_system_score_gemma":0.0001742199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006720552,"about_ca_topic_score_gemma":0.0008551401,"domain_scores_codex":[0.9998253,0.00003537898,0.00001641476,0.00003622314,0.00005831227,0.0000284071],"domain_scores_gemma":[0.9998947,0.00001862324,0.00004144371,0.00001545403,0.0000153846,0.00001430769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008230043,0.00002190242,0.001437755,0.00003208211,0.00001307386,0.000157001,0.00001665789,0.0001136825,0.9958013,0.0001059584,0.00005403343,0.002164382],"study_design_scores_gemma":[0.00003283402,0.000814789,0.03519718,0.00002140464,0.000122055,0.003349708,0.0001166897,0.002120546,0.9491053,0.0001776181,0.008922724,0.00001921681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947141,0.0009666549,0.002330518,0.00009211223,0.00003506771,0.0000318657,0.0002670607,0.00003551822,0.00152706],"genre_scores_gemma":[0.9962727,0.0004885355,0.001849268,0.00007277688,0.00001195225,0.00001357148,0.0004892598,0.00001946349,0.0007824972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001067715,"threshold_uncertainty_score":0.003571928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0238802188539845,"score_gpt":0.2938179485628432,"score_spread":0.2699377297088587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}