{"id":"W4408344009","doi":"10.1093/neuonc/noaf061","title":"Germline analysis of an international cohort of pediatric diffuse midline glioma patients","year":2025,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; McGill University; McGill Genome Centre; Université de Montréal; McGill University Health Centre","funders":"Medical Research Future Fund; Australian Lions Childhood Cancer Research Foundation","keywords":"Germline; PALB2; Germline mutation; Carcinogenesis; Genetics; Cancer research; Medicine; Glioma; Exome sequencing; Biology; Cancer; Oncology; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001022829,0.0001200631,0.0006223917,0.001096402,0.00001814627,0.000002959976,0.0001333633,0.0001060193,0.0001569484],"category_scores_gemma":[0.0002695356,0.0000912036,0.0002030204,0.001106643,0.00005531173,0.00004189759,0.00007188133,0.00008710921,0.000002932099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001000087,"about_ca_system_score_gemma":0.000107927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006182312,"about_ca_topic_score_gemma":0.00004610698,"domain_scores_codex":[0.9987478,0.00007786944,0.0005233684,0.0002761197,0.0002403373,0.0001345332],"domain_scores_gemma":[0.9987193,0.0002744017,0.0002569412,0.0003256397,0.0003403524,0.0000833627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002744502,0.00697648,0.9664227,0.00002268885,0.001384841,0.000104476,0.00004515508,0.00003588693,0.01741032,0.00007542664,0.0003939459,0.006853605],"study_design_scores_gemma":[0.005136095,0.001165114,0.9706663,0.000005419355,0.005115256,0.00000329388,0.000009683331,0.0009007303,0.01466254,0.00001390683,0.002268966,0.00005262918],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974229,0.00005655525,0.00001073572,0.0007062404,0.0004215456,0.0002953651,0.00008823618,0.00001734192,0.0009810441],"genre_scores_gemma":[0.9987936,0.0001407179,0.0002348688,0.0003602715,0.00008161781,0.00003317792,0.0003307239,0.00000877584,0.00001623726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006800976,"threshold_uncertainty_score":0.3719175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126072843836096,"score_gpt":0.3159108740904547,"score_spread":0.3033035897068451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}