{"id":"W4408345976","doi":"10.1093/brain/awaf103","title":"Modulating inhibitory synaptic plasticity to restore basal ganglia dynamics in Parkinson's disease","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Parkinson Canada","keywords":"Neuroscience; Basal ganglia; Inhibitory postsynaptic potential; Parkinson's disease; Synaptic plasticity; Homeostatic plasticity; Psychology; Biology; Disease; Medicine; Central nervous system; Metaplasticity; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005671543,0.0001132228,0.0001757511,0.0001202014,0.00004211376,0.000009395519,0.00005052608,0.00005301355,0.0000210845],"category_scores_gemma":[0.0008593068,0.00009699455,0.00004692648,0.0002431802,0.00003162605,0.00002341445,0.00006056751,0.0001331721,0.00002010814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001527099,"about_ca_system_score_gemma":0.00006086503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004752332,"about_ca_topic_score_gemma":0.0001736716,"domain_scores_codex":[0.9992011,0.00004388281,0.0001511244,0.0002763019,0.0001174844,0.0002101188],"domain_scores_gemma":[0.9994979,0.0001665591,0.00002055338,0.0001408562,0.00001702177,0.0001571279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008464757,0.0006143523,0.9789651,0.0001073101,0.0000419344,0.001193605,0.00005530714,0.0003718268,0.0003026984,0.00335749,0.008012249,0.00613164],"study_design_scores_gemma":[0.001428599,0.0001887383,0.9600987,0.0001669822,0.00003364131,3.111082e-7,0.00004636531,0.03084266,0.00001811451,0.006644222,0.0004364614,0.00009522928],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856193,0.00006344669,0.0003973809,0.01154257,0.0001057707,0.0003574361,0.00001561746,0.00004839577,0.001850045],"genre_scores_gemma":[0.9880407,0.000001894672,0.0001803574,0.01074801,0.00002777703,0.00003606882,0.00001484626,0.0000101789,0.0009401605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03047084,"threshold_uncertainty_score":0.3955323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01176534622244664,"score_gpt":0.2670100594499969,"score_spread":0.2552447132275503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}