{"id":"W4408348202","doi":"10.1055/s-0045-1804283","title":"Symptomatic skeletal events, health-related quality of life and pain in a phase III study of [177Lu]Lu-PSMA-617 in taxane-naive patients with PSMA-positive metastatic castration-resistant prostate cancer: Third interim analysis of PSMAfore","year":2025,"lang":"en","type":"article","venue":"Nuklearmedizin - NuclearMedicine","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Taxane; Prostate cancer; Medicine; Oncology; Internal medicine; Quality of life (healthcare); Castration; Cancer; Breast cancer; Hormone; Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00296895,0.001518602,0.003005227,0.0003933706,0.0005934547,0.001414754,0.001124694,0.001600067,0.002523051],"category_scores_gemma":[0.001010356,0.0007467399,0.003036696,0.0005677844,0.001239033,0.001109942,0.0004632439,0.003601854,0.0006926265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001038736,"about_ca_system_score_gemma":0.001907165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002266495,"about_ca_topic_score_gemma":0.005993483,"domain_scores_codex":[0.9990006,0.0005081565,0.00003686856,0.0001072325,0.0001109432,0.0002361419],"domain_scores_gemma":[0.9990736,0.0001866524,0.0001912656,0.000124871,0.00004820908,0.0003753608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9141924,0.0216123,0.0158984,0.000209735,0.003314988,0.0001064415,0.0002227518,0.002411213,0.01273046,0.0001279651,0.0009746364,0.02819872],"study_design_scores_gemma":[0.4907158,0.4143962,0.0828779,0.00003237539,0.003506651,0.0002300396,0.0001682032,0.002093885,0.004286769,0.0002727726,0.001333099,0.00008615565],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975516,0.0007001814,0.0002088597,0.0001216691,0.00002990523,0.0002992605,0.0005195885,0.00002810162,0.0005408348],"genre_scores_gemma":[0.9948851,0.0005924099,0.0005636644,0.0003073476,0.00005909064,0.0005314682,0.001753466,0.00002885214,0.001278662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003005227,"threshold_uncertainty_score":0.01570153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0277435034128749,"score_gpt":0.3736595364562402,"score_spread":0.3459160330433653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}