{"id":"W4408348816","doi":"10.1016/j.oret.2025.03.004","title":"Best Vitelliform Macular Dystrophy Natural History Study Report 2","year":2025,"lang":"en","type":"article","venue":"Ophthalmology Retina","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology; Moorfields Eye Hospital NHS Foundation Trust; Ministry of Health, Labour and Welfare; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Astellas Pharma; Wellcome Trust; Foundation Fighting Blindness; Japan Agency for Medical Research and Development; UCL Institute of Ophthalmology, University College London; Alnylam Pharmaceuticals","keywords":"Optical coherence tomography; Medicine; Ophthalmology; Macular dystrophy; Fundus (uterus); Optometry; Autofluorescence; Natural history; Retinal; Optics; Internal medicine; Fluorescence; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004929141,0.0002817422,0.0003747458,0.0007815087,0.0005842355,0.0004462128,0.000339559,0.0003982858,0.002314103],"category_scores_gemma":[0.001382797,0.000259881,0.0003921326,0.0005925812,0.0001414867,0.0003484896,0.0003940385,0.0003375035,0.000403876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003206181,"about_ca_system_score_gemma":0.0003496892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002825449,"about_ca_topic_score_gemma":0.003266005,"domain_scores_codex":[0.9995508,0.00009772055,0.00004445167,0.0001584024,0.00007794699,0.00007070079],"domain_scores_gemma":[0.9990638,0.0001217781,0.0004197395,0.00007201587,0.0001119037,0.0002108265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001972274,0.00007132911,0.9968268,0.00001447147,0.00004283199,0.0008152779,0.00007762835,0.00002315775,0.0004315815,0.00001736563,0.0002918653,0.001190423],"study_design_scores_gemma":[0.00006281245,0.0001842112,0.9932486,0.00001543405,0.00005208219,0.005589741,0.0000888654,0.00008329935,0.0001071006,0.00002199696,0.0005401331,0.00000563129],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997942,0.0002000836,0.00009518994,0.0000465834,0.0000045927,0.00003596763,0.0009936977,0.000005799911,0.0006759693],"genre_scores_gemma":[0.9972261,0.0001016476,0.000189067,0.00007038516,0.00002378234,0.0000408556,0.001933012,0.000004767468,0.0004103904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002825449,"threshold_uncertainty_score":0.007741392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012655248554714,"score_gpt":0.2718383896199064,"score_spread":0.2617118371343592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}