{"id":"W4408348816","doi":"10.1016/j.oret.2025.03.004","title":"Best Vitelliform Macular Dystrophy Natural History Study Report 2","year":2025,"lang":"en","type":"article","venue":"Ophthalmology Retina","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology; Moorfields Eye Hospital NHS Foundation Trust; Ministry of Health, Labour and Welfare; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Astellas Pharma; Wellcome Trust; Foundation Fighting Blindness; Japan Agency for Medical Research and Development; UCL Institute of Ophthalmology, University College London; Alnylam Pharmaceuticals","keywords":"Optical coherence tomography; Medicine; Ophthalmology; Macular dystrophy; Fundus (uterus); Optometry; Autofluorescence; Natural history; Retinal; Optics; Internal medicine; Fluorescence; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002607504,0.0002403909,0.000244225,0.0001043273,0.0001031168,0.00001227741,0.0002968399,0.0002018926,0.0001347532],"category_scores_gemma":[0.0001410745,0.0002287234,0.0001235637,0.000123825,0.0001697786,0.000004082991,0.0002109207,0.0001837412,0.00005251198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007209333,"about_ca_system_score_gemma":0.0001897695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004181231,"about_ca_topic_score_gemma":0.000003952945,"domain_scores_codex":[0.9985096,0.00008737171,0.0003431513,0.0005898523,0.000140114,0.00032994],"domain_scores_gemma":[0.9991826,0.00001030983,0.0001181967,0.0005162046,0.0001139541,0.00005867717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008408994,0.001102342,0.8510104,0.00008314936,0.0003956232,0.006424622,0.0001638025,0.000007809,0.1049661,0.0002932869,0.03294319,0.001768775],"study_design_scores_gemma":[0.003315235,0.002819069,0.2558497,0.00007329816,0.0002724103,0.009417775,0.001327625,0.00002830008,0.0176755,0.0006154359,0.7071515,0.001454145],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9118233,0.002943365,0.0000353848,0.0001579614,0.001027125,0.0003525042,0.000001425977,0.0000177778,0.08364119],"genre_scores_gemma":[0.9420018,0.00003981928,0.0003613059,0.0001388684,0.00007722708,0.00005794255,0.0001554209,0.00001923623,0.05714838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6742083,"threshold_uncertainty_score":0.9327071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012655248554714,"score_gpt":0.2718383896199064,"score_spread":0.2617118371343592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}