{"id":"W4408357303","doi":"10.1016/j.jchf.2024.12.010","title":"Effects of Sacubitril/Valsartan According to Natriuretic Peptide Levels in Patients Enrolled in PARADIGM-HF and PARAGON-HF","year":2025,"lang":"en","type":"article","venue":"JACC Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Relypsa; Novartis Pharma; Ono Pharmaceutical; University of Glasgow; Great Britain Sasakawa Foundation; British Heart Foundation; Kowa Company; Regeneron Pharmaceuticals; Novartis Pharmaceuticals Corporation; Abbott Japan; LivaNova; Boston Scientific Corporation; Bayer; Intas Pharmaceuticals; AstraZeneca; Alnylam Pharmaceuticals; Amgen","keywords":"Sacubitril, Valsartan; Medicine; Sacubitril; Heart failure; Valsartan; Internal medicine; Natriuretic peptide; Cardiology; Ejection fraction; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003938977,0.0003018875,0.001095809,0.0008080098,0.00005230205,0.00002706597,0.00009242322,0.0001730108,0.00002475553],"category_scores_gemma":[0.0004399894,0.0002667103,0.0001118307,0.0009683539,0.00004017858,0.0001225994,0.0001282431,0.0002704892,0.00003006915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001798239,"about_ca_system_score_gemma":0.0001226266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001791739,"about_ca_topic_score_gemma":0.000202533,"domain_scores_codex":[0.9979429,0.0001504916,0.0005913857,0.0004952226,0.0003137471,0.0005062643],"domain_scores_gemma":[0.9989374,0.0004181792,0.00006391688,0.0003393227,0.00005532313,0.0001858937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004869988,0.000693194,0.9777446,0.0009200301,0.0001030721,0.00009792754,0.0006468481,0.00001669277,0.003140674,0.0004927547,0.01285646,0.002800757],"study_design_scores_gemma":[0.01186585,0.000641868,0.9452281,0.001496578,0.0001506452,0.000003994171,0.0002719032,0.00006189846,0.005458826,0.0002380846,0.03430871,0.0002735282],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839032,0.0003262429,0.00004551792,0.0125319,0.0001358198,0.002719427,0.000004693441,0.00004144597,0.0002917729],"genre_scores_gemma":[0.9951953,0.00002098161,0.002883181,0.001055073,0.00003602984,0.0001703434,0.00001103891,0.00002441582,0.0006035787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03251647,"threshold_uncertainty_score":0.9999785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006223898178026726,"score_gpt":0.2654028826509762,"score_spread":0.2591789844729495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}