{"id":"W4408357303","doi":"10.1016/j.jchf.2024.12.010","title":"Effects of Sacubitril/Valsartan According to Natriuretic Peptide Levels in Patients Enrolled in PARADIGM-HF and PARAGON-HF","year":2025,"lang":"en","type":"article","venue":"JACC Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Relypsa; Novartis Pharma; Ono Pharmaceutical; University of Glasgow; Great Britain Sasakawa Foundation; British Heart Foundation; Kowa Company; Regeneron Pharmaceuticals; Novartis Pharmaceuticals Corporation; Abbott Japan; LivaNova; Boston Scientific Corporation; Bayer; Intas Pharmaceuticals; AstraZeneca; Alnylam Pharmaceuticals; Amgen","keywords":"Sacubitril, Valsartan; Medicine; Sacubitril; Heart failure; Valsartan; Internal medicine; Natriuretic peptide; Cardiology; Ejection fraction; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001831814,0.0005549471,0.001429444,0.0002703039,0.0002100639,0.0005193217,0.0003238503,0.0006592615,0.00108045],"category_scores_gemma":[0.002750456,0.0002550091,0.001887154,0.0002102033,0.0002865222,0.0005625949,0.000563202,0.0007814781,0.00009058369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002991126,"about_ca_system_score_gemma":0.0005218275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006166271,"about_ca_topic_score_gemma":0.001979416,"domain_scores_codex":[0.9990904,0.0004200054,0.0001099498,0.0001955049,0.00006222328,0.0001219306],"domain_scores_gemma":[0.998458,0.0004477106,0.0004038001,0.0001359529,0.0001125839,0.000441813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7465442,0.004497879,0.1724497,0.0006492403,0.005459347,0.0001942503,0.000186134,0.000705219,0.003822462,0.0002860288,0.001547393,0.06365813],"study_design_scores_gemma":[0.130558,0.1678479,0.689198,0.0001659881,0.004623873,0.0004790053,0.0003869692,0.002461307,0.001387551,0.001288097,0.001498129,0.0001051493],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975936,0.001575525,0.00006368208,0.0001224655,0.00004291434,0.00006300286,0.0001685221,0.00000494738,0.0003652532],"genre_scores_gemma":[0.9984233,0.0003015471,0.000204072,0.0002738468,0.00008595314,0.00007389815,0.0004733484,0.00000120831,0.0001627634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001831814,"threshold_uncertainty_score":0.009687662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006223898178026726,"score_gpt":0.2654028826509762,"score_spread":0.2591789844729495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}