{"id":"W4408363509","doi":"10.1158/1078-0432.ccr-24-3301","title":"Update on Cancer Screening Recommendations for Individuals with Li–Fraumeni Syndrome","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Li–Fraumeni syndrome; Medicine; Cancer; Germline; Genetic predisposition; Population; Intervention (counseling); Modalities; Oncology; Germline mutation; Internal medicine; Gene; Genetics; Mutation; Environmental health; Psychiatry; Biology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002253958,0.0002155443,0.0005647989,0.0004461922,0.0003474539,0.00007102748,0.000304624,0.0002562184,0.0007707521],"category_scores_gemma":[0.000603766,0.0001638674,0.0001571813,0.001281534,0.0004113544,0.00007854734,0.0001451717,0.00161944,0.00004113575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004276804,"about_ca_system_score_gemma":0.001975705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004768252,"about_ca_topic_score_gemma":0.0006054884,"domain_scores_codex":[0.9967664,0.0002830427,0.0005946239,0.0008146652,0.0007914702,0.0007497667],"domain_scores_gemma":[0.9968408,0.001281324,0.0001158507,0.0007088275,0.0007196025,0.0003335347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01383866,0.001367935,0.09032033,0.0007334729,0.00362589,0.0002713453,0.0002237038,0.0007899095,0.0003628288,0.00395574,0.3939182,0.490592],"study_design_scores_gemma":[0.0120848,0.004301975,0.0244884,0.004484824,0.0003829932,0.00002392278,0.0001724039,0.0003946219,0.00224638,0.0004440631,0.9506277,0.0003478584],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6497828,0.005307163,0.01351496,0.3104527,0.001406118,0.008777033,0.001115831,0.0003569574,0.009286442],"genre_scores_gemma":[0.948795,0.004699938,0.0136004,0.01132453,0.0007566203,0.007066373,0.0003368618,0.0002008221,0.01321945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5567096,"threshold_uncertainty_score":0.8439195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2692035386000909,"score_gpt":0.5625922580384279,"score_spread":0.2933887194383371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}