{"id":"W4408363509","doi":"10.1158/1078-0432.ccr-24-3301","title":"Update on Cancer Screening Recommendations for Individuals with Li–Fraumeni Syndrome","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Li–Fraumeni syndrome; Medicine; Cancer; Germline; Genetic predisposition; Population; Intervention (counseling); Modalities; Oncology; Germline mutation; Internal medicine; Gene; Genetics; Mutation; Environmental health; Psychiatry; Biology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008641216,0.0005945063,0.0008901597,0.00315205,0.000941033,0.001480132,0.002617469,0.005048982,0.007111745],"category_scores_gemma":[0.02843393,0.0004513156,0.002053551,0.00187781,0.0005735775,0.001656373,0.00212005,0.006735805,0.004752869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002867565,"about_ca_system_score_gemma":0.007687353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01965244,"about_ca_topic_score_gemma":0.02641534,"domain_scores_codex":[0.9950788,0.001577948,0.001266573,0.0002246245,0.001482306,0.000369765],"domain_scores_gemma":[0.9809523,0.004580711,0.001454886,0.0003187315,0.01151098,0.001182426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000545075,0.00007299908,0.002345804,0.00130032,0.00005782258,0.0002737817,0.0002121889,0.0004589889,0.0003888316,0.002605737,0.7482057,0.2440233],"study_design_scores_gemma":[0.00004958893,0.00005721204,0.004635214,0.005490766,0.0001480668,0.0007169933,0.0001992413,0.0002235098,0.0003154874,0.001933574,0.9861909,0.0000394819],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.005873036,0.1795206,0.02120867,0.6365511,0.02621659,0.001899105,0.01275173,0.001931716,0.1140475],"genre_scores_gemma":[0.04374003,0.3542793,0.09985768,0.3680881,0.01677755,0.005151723,0.04491939,0.000740729,0.06644545],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01965244,"threshold_uncertainty_score":0.04569966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2692035386000909,"score_gpt":0.5625922580384279,"score_spread":0.2933887194383371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}