{"id":"W4408375460","doi":"10.3390/ijms26062546","title":"Differential H3K4me3 Domains in Normal and Colorectal Cancer Cells Reveal Novel Epigenetic Targets","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Research Institute in Oncology and Hematology; University of Manitoba; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; CancerCare Manitoba Foundation","keywords":"H3K4me3; Epigenetics; Biology; Colorectal cancer; Cancer research; Histone; Gene; Cancer; Genetics; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005889825,0.0001293404,0.0001386233,0.0002989811,0.0001871417,0.0001641246,0.0001149455,0.0001594643,0.0009694009],"category_scores_gemma":[0.00009525182,0.0001000449,0.0001557313,0.0002255662,0.0001850468,0.00009306851,0.0001339241,0.0002200417,0.0001872496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003096133,"about_ca_system_score_gemma":0.0001871013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002079454,"about_ca_topic_score_gemma":0.004112987,"domain_scores_codex":[0.9999269,0.000004926597,0.000003945358,0.00002473015,0.00001846492,0.00002095688],"domain_scores_gemma":[0.9999553,0.000008027844,0.000008529158,0.000006753409,0.000007975725,0.0000133684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008693668,0.000003937211,0.001350096,0.00001711153,0.000003883137,0.00004219041,0.00001468337,0.00003411503,0.997453,0.00005107372,0.00002081627,0.000922139],"study_design_scores_gemma":[0.00001857293,0.0001580813,0.1338511,0.000003491602,0.00003056904,0.0007621175,0.0001069809,0.001121873,0.8599783,0.0001480133,0.003812069,0.000008932551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995676,0.001065044,0.00173685,0.00005618796,0.000009176449,0.00000766042,0.0005354518,0.00003692858,0.0008767527],"genre_scores_gemma":[0.9965106,0.0003173482,0.001084422,0.00003290934,0.000002199022,0.000009510831,0.0007663106,0.00000692508,0.001269775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002079454,"threshold_uncertainty_score":0.004134655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007370516792477589,"score_gpt":0.2977149325659317,"score_spread":0.2903444157734542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}