{"id":"W4408383416","doi":"10.1002/ejhf.3636","title":"Update on Preclinical Models of Cancer Therapy-Related Cardiac Dysfunction: Challenges and Perspectives. A Scientific Statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio-Oncology, and the ESC Working Group on Cellular Biology of the Heart","year":2025,"lang":"en","type":"review","venue":"European Journal of Heart Failure","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"Instituto de Salud Carlos III; Biotechnology and Biological Sciences Research Council; Horizon 2020 Framework Programme; Directorate for Biological Sciences; National Institutes of Health; Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares; Ministerio de Ciencia e Innovación; National Heart, Lung, and Blood Institute; Ministero della Salute; Genentech; Deutsche Krebshilfe; Fondation Leducq; European Regional Development Fund; European Commission; Deutsche Forschungsgemeinschaft; UK Research and Innovation; “la Caixa” Foundation; Ministerio de Ciencia, Innovación y Universidades; Università degli Studi di Torino; Ministero dell’Istruzione, dell’Università e della Ricerca; Comunidad de Madrid","keywords":"Medicine; Heart failure; Statement (logic); Cancer therapy; Cancer; Internal medicine; Cardiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002785128,0.001043056,0.001949952,0.002947546,0.0002568286,0.001495051,0.001490949,0.002092975,0.003152945],"category_scores_gemma":[0.002522377,0.0004849464,0.0009149832,0.002143718,0.00075389,0.002893992,0.0008618286,0.003318095,0.002230078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007778069,"about_ca_system_score_gemma":0.001639209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001060255,"about_ca_topic_score_gemma":0.001931454,"domain_scores_codex":[0.9994336,0.000146235,0.0001106371,0.00005693981,0.0002149044,0.00003764252],"domain_scores_gemma":[0.997403,0.001488365,0.0002725132,0.00006298956,0.0006367378,0.0001364823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001645756,0.0001620063,0.0001832657,0.02714558,0.0001387264,0.0002700243,0.0001042214,0.00046452,0.003746788,0.008642701,0.153787,0.8051906],"study_design_scores_gemma":[0.00001712454,0.0001218465,0.0003064934,0.00264285,0.000104777,0.0005923588,0.00002819253,0.00007296732,0.0004454266,0.001153067,0.9944977,0.000017229],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006928503,0.9976285,0.0001706242,0.0007657278,0.0007593096,0.000005791993,0.00004047038,0.00001166018,0.0005485449],"genre_scores_gemma":[0.0004579484,0.997013,0.0003499041,0.0007951567,0.000699396,0.00001235441,0.00009938904,0.000004623767,0.0005682059],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003152945,"threshold_uncertainty_score":0.01472938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08046618421815467,"score_gpt":0.3127833473760879,"score_spread":0.2323171631579333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}