{"id":"W4408384398","doi":"10.1002/ctd2.70038","title":"Commentary on ‘Lentivirus‐mediated gene therapy for Fabry disease: 5‐year end‐of‐study results from the Canadian FACTS trial’","year":2025,"lang":"en","type":"article","venue":"Clinical and Translational Discovery","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondazione Telethon; European Commission","keywords":"Genetic enhancement; Lentivirus; Medicine; Fabry disease; Virology; Clinical trial; Disease; Oncology; Gene; Pediatrics; Genetics; Biology; Internal medicine; Human immunodeficiency virus (HIV); Viral disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000542685,0.0001256975,0.000290326,0.00006784444,0.000190712,0.00003974099,0.000122838,0.00008458984,0.00004043753],"category_scores_gemma":[0.0005233954,0.00008123731,0.0001965984,0.0001456203,0.0002670254,0.00007903876,0.00001497876,0.0002315848,0.000004445834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001829694,"about_ca_system_score_gemma":0.0006456818,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01356799,"about_ca_topic_score_gemma":0.02181676,"domain_scores_codex":[0.9984187,0.0001874494,0.000526674,0.0003408859,0.000344277,0.00018205],"domain_scores_gemma":[0.9960746,0.003358524,0.0000558054,0.0002517317,0.00007048272,0.0001888537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2110548,0.00349626,0.7439262,0.00003107987,0.00101696,0.00002447737,0.0003673584,0.00001339854,0.00002888987,0.0008293626,0.01323387,0.02597735],"study_design_scores_gemma":[0.06531131,0.0007388449,0.9212564,0.00005806523,0.0001076924,5.526616e-8,0.00009264429,0.0001146226,0.00002422857,0.002508348,0.009703381,0.00008442941],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9450827,0.0008981126,0.00009573594,0.04705285,0.0002469706,0.00222548,0.003942057,0.000009736864,0.0004463187],"genre_scores_gemma":[0.9921429,0.0002958529,0.00002682656,0.005283922,0.0002282801,0.00007020764,0.001731885,0.00001068935,0.0002094246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1773302,"threshold_uncertainty_score":0.9960325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08319845578048332,"score_gpt":0.387003429268415,"score_spread":0.3038049734879317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}