{"id":"W4408384398","doi":"10.1002/ctd2.70038","title":"Commentary on ‘Lentivirus‐mediated gene therapy for Fabry disease: 5‐year end‐of‐study results from the Canadian FACTS trial’","year":2025,"lang":"en","type":"article","venue":"Clinical and Translational Discovery","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondazione Telethon; European Commission","keywords":"Genetic enhancement; Lentivirus; Medicine; Fabry disease; Virology; Clinical trial; Disease; Oncology; Gene; Pediatrics; Genetics; Biology; Internal medicine; Human immunodeficiency virus (HIV); Viral disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01795823,0.001375302,0.003097446,0.001080435,0.002053134,0.003377365,0.004936624,0.02754736,0.007379201],"category_scores_gemma":[0.0495416,0.0007763525,0.003693223,0.001614638,0.002390119,0.003058506,0.001091535,0.02085665,0.004984632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006966147,"about_ca_system_score_gemma":0.009078274,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0244482,"about_ca_topic_score_gemma":0.04129549,"domain_scores_codex":[0.9900045,0.003856013,0.00126236,0.0009300748,0.003114921,0.0008321821],"domain_scores_gemma":[0.9523855,0.03060826,0.002027268,0.0009066784,0.01082504,0.003247187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000872031,0.00001767589,0.0001607473,0.0004255814,0.00009339226,0.0001514546,0.00003993787,0.0000964303,0.00018929,0.0007464312,0.9831255,0.01408143],"study_design_scores_gemma":[0.001999625,0.0003526546,0.001765098,0.001917258,0.0004910995,0.0003115233,0.00007407708,0.0004145459,0.0004030401,0.003379099,0.9887422,0.0001499708],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0006388046,0.01402355,0.0005472423,0.8794189,0.09909526,0.0001674642,0.001562579,0.0001704485,0.004375787],"genre_scores_gemma":[0.003390717,0.004228329,0.0005474274,0.9210261,0.0661742,0.0001843972,0.0004876139,0.00007564521,0.003885541],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.9755518,"threshold_uncertainty_score":0.09497339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08319845578048332,"score_gpt":0.387003429268415,"score_spread":0.3038049734879317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}