{"id":"W4408389645","doi":"10.1038/s41467-026-72168-3","title":"NCOR2 represses MHC class I molecule expression to drive metastatic progression of breast cancer","year":2025,"lang":"en","type":"preprint","venue":"Nature Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Biology; MHC class I; Cancer research; CD8; Major histocompatibility complex; Corepressor; Metastasis; Cancer; Immunotherapy; T cell; Regulator; Immune system; Immunology; Nuclear receptor; Transcription factor; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382733,0.0002010241,0.0001543654,0.0001368989,0.0001097259,0.0002569614,0.0001463851,0.0001778638,0.003119926],"category_scores_gemma":[0.0001253136,0.00008478589,0.0001469299,0.0001004202,0.0001669561,0.0001151769,0.0001861897,0.0004134116,0.0007510282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002563567,"about_ca_system_score_gemma":0.000232642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000590146,"about_ca_topic_score_gemma":0.001242085,"domain_scores_codex":[0.9998991,0.00001262277,0.0000042584,0.00001876645,0.00004092829,0.00002428494],"domain_scores_gemma":[0.9999361,0.00001082304,0.00001281093,0.00001282108,0.000008840251,0.00001870068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007002163,0.00001715757,0.0002238776,0.00002184664,0.000003535109,0.00005425263,0.000008463988,0.0000769208,0.9974354,0.0003526573,0.0002027755,0.001533167],"study_design_scores_gemma":[0.000030106,0.0001659306,0.004381643,0.000005190519,0.000008645394,0.0003163185,0.00002637759,0.001562721,0.9835783,0.0001544117,0.009767266,0.000003094297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750673,0.002217544,0.007333585,0.0005870232,0.0001902346,0.00005433549,0.0008482359,0.0003386357,0.0133631],"genre_scores_gemma":[0.9798431,0.000762097,0.002793038,0.0001394615,0.00003494944,0.00003000151,0.000893416,0.00007254929,0.01543151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003119926,"threshold_uncertainty_score":0.01043713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01867410370835369,"score_gpt":0.3538073794759211,"score_spread":0.3351332757675674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}