{"id":"W4408392635","doi":"10.1016/j.ymthe.2025.03.018","title":"CD47 peptide-cloaked lipid nanoparticles promote cell-specific mRNA delivery","year":2025,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"NHLBI Division of Intramural Research; National Institutes of Health; National Heart, Lung, and Blood Institute; University of Pennsylvania","keywords":"CD47; Peptide; Messenger RNA; Cell biology; Cell; Nanoparticle; Chemistry; Biology; Biochemistry; Nanotechnology; Gene; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001446744,0.0002695421,0.000201204,0.00008737241,0.0001167587,0.0000731109,0.0004052467,0.0001816221,0.00007973117],"category_scores_gemma":[0.00001058751,0.0002565442,0.0002124192,0.0001888672,0.00008868722,0.000006799513,0.0001107067,0.0001223909,0.0001234572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002011928,"about_ca_system_score_gemma":0.00009057041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001845595,"about_ca_topic_score_gemma":0.000004124129,"domain_scores_codex":[0.9985249,0.0001008151,0.0002795966,0.0005498824,0.0001620761,0.0003827346],"domain_scores_gemma":[0.9990312,0.000007724493,0.00007024025,0.0006679745,0.0001406443,0.00008214229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002404854,0.0001461161,0.0003965829,0.000009471614,0.00009678874,0.00002185338,0.00005650968,0.0000428269,0.9736121,0.00007682045,0.01071515,0.0145853],"study_design_scores_gemma":[0.0008086005,0.0003073011,0.0004192553,0.00002108078,0.000009698396,0.000004301769,0.00004267838,0.00002257201,0.8212468,0.0001427563,0.176743,0.0002319247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837998,0.01048688,0.001441847,0.0003220151,0.000290526,0.0003042612,0.000008800801,0.00003802517,0.003307921],"genre_scores_gemma":[0.9908416,0.003105921,0.000526173,0.001763675,0.0001225353,0.00002693,0.00006099293,0.00003452363,0.0035177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1660279,"threshold_uncertainty_score":0.9999887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009097367844338502,"score_gpt":0.2312004164088156,"score_spread":0.2221030485644771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}