{"id":"W4408392635","doi":"10.1016/j.ymthe.2025.03.018","title":"CD47 peptide-cloaked lipid nanoparticles promote cell-specific mRNA delivery","year":2025,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"NHLBI Division of Intramural Research; National Institutes of Health; National Heart, Lung, and Blood Institute; University of Pennsylvania","keywords":"CD47; Peptide; Messenger RNA; Cell biology; Cell; Nanoparticle; Chemistry; Biology; Biochemistry; Nanotechnology; Gene; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001050293,0.0002391343,0.000150183,0.0001078591,0.00007955753,0.0002411468,0.00008340198,0.0002744345,0.0007639895],"category_scores_gemma":[0.0001016961,0.0001051561,0.0001242956,0.00006061723,0.0001797697,0.0001634497,0.0001613575,0.0002481515,0.0003086869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002081131,"about_ca_system_score_gemma":0.0001865654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003376768,"about_ca_topic_score_gemma":0.0004782357,"domain_scores_codex":[0.9999318,0.00001052277,0.000004487772,0.00001634749,0.00001726469,0.00001945916],"domain_scores_gemma":[0.9999497,0.00001408479,0.00001512197,0.000004041859,0.000007983411,0.000009085782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003152064,0.00001162534,0.00003883248,0.00002475577,0.000001472411,0.00003262323,0.00001123528,0.0001195871,0.9980243,0.000163983,0.00004803116,0.001492043],"study_design_scores_gemma":[0.000006583074,0.0001023669,0.0001816388,0.000002025077,0.000004189036,0.00003305926,0.000005778841,0.0009001875,0.9974537,0.00002310421,0.001285884,0.000001619805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830747,0.001360664,0.01188624,0.0001480894,0.00006007546,0.00005032386,0.00008348012,0.0001809148,0.003155542],"genre_scores_gemma":[0.9898674,0.0008529247,0.005648798,0.00008840552,0.00001511556,0.0000369364,0.00007565042,0.00003203463,0.003382674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007639895,"threshold_uncertainty_score":0.002555788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009097367844338502,"score_gpt":0.2312004164088156,"score_spread":0.2221030485644771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}